The Clinical Relevance of the Bone Vascular System: Age-Related Implications

  • Rhonda D. PrisbyEmail author
Review Paper


]The microcirculation of bone and marrow is vital for bone development, maintenance, and repair. In addition to the well-known function of transporting oxygen, nutrients, systemic hormones, precursor cells, waste, etc., the bone vascular network plays a role in the mechanical induction of bone formation. In addition, arteries and marrow sinusoids are critical components of hematopoietic stem cell niches. This review discusses the various roles of the bone and marrow microcirculation in regard to (1) bone development, remodeling, and fracture repair; (2) the regulation of bone intramedullary pressure and interstitial fluid flow; and (3) the mobilization of mature blood cells into the peripheral circulation. Age-associated dysfunction of the microcirculation is discussed in relation to how it may disturb bone and marrow homeostasis, fracture repair, and organismal vitality. Finally, the review invites the reader to consider the efficacy of treatments designed to alleviate bone and marrow pathologies in the face of a compromised vascular network.


Microcirculation Bone Marrow Blood flow Blood cells 


Compliance with Ethical Standards

Conflict of Interest

The author declares that she has no conflicts of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Bone Vascular and Microcirculation Laboratory, Department of KinesiologyUniversity of Texas at ArlingtonArlingtonUSA

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