Clinical Reviews in Bone and Mineral Metabolism

, Volume 10, Issue 3, pp 149–162

Biochemical Abnormalities in Chronic Kidney Disease–Mineral Bone Disease

Original Paper


Chronic kidney disease–mineral and bone disorders (CKD-MBD) is a term introduced by the Kidney Disease: Improving Global Outcomes (KDIGO) work group on mineral and bone disorder as a syndrome of interrelated biochemical, bone, and vascular abnormalities encountered in CKD. Biochemical abnormalities in CKD represent primary indicators for the diagnosis and management of CKD-MBD. This review discusses each abnormality separately, with references to both the Kidney Dialysis Outcomes Quality Initiative (KDOQI) Clinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease and KDIGO Guidelines for Mineral and Bone Disorder. Selected references to the association between biochemical abnormalities and adverse clinical outcomes in CKD population are provided.


Kidney Bone Mineral CKD-MBD Phosphorus Calcium Parathyroid hormone FGF-23 25-hydroxyvitamin D 1,25-dihydroxyvitamin D 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Division of Nephrology and Hypertension, Department of MedicineUniversity Hospitals Case Medical CenterClevelandUSA

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