Vitamin D Regulation of Immune Function: Implications for Bone Loss During Inflammation
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Although the best known actions of vitamin D involve its regulation of bone mineral homeostasis, actions critical for a healthy skeleton, vitamin D exerts its influence on many physiologic processes. One of these processes is the immune system. Both the adaptive and innate immune systems are impacted by the active metabolite of vitamin D, 1,25(OH)2D3. In turn, the immune system is now recognized as having a major impact on the skeleton. In this review, I will examine the regulation by 1,25(OH)2D3 of immune function, then examine the evidence for such regulation as potential means of ameliorating the bone loss that accompanies the inflammatory state.
KeywordsVitamin D Innate immunity Adaptive immunity Macrophage Keratinocyte Osteoclast
This work was supported by grants RO1 AR050023 and AR051930 from the National Institutes of Health, a Merit Review from the Department of Veterans Affairs, and grant 07A140 from the American Institute of Cancer Research.
- 5.Bikle DD. Extra renal synthesis of 1,25-dihydroxyvitamin D and its health implications. In: Holick MFE, editor. Vitamin D: physiology, molecular biology, and clinical applications. Humana Press; 1999.Google Scholar
- 53.Palmqvist P, Lundberg P, Persson E, Johansson A, Lundgren I, Lie A, et al. Inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathway. J Biol Chem. 2006;281:2414–29.CrossRefPubMedGoogle Scholar