Clinical Reviews in Bone and Mineral Metabolism

, Volume 7, Issue 4, pp 301–309

Vitamin D Regulation of Immune Function: Implications for Bone Loss During Inflammation

Original Paper


Although the best known actions of vitamin D involve its regulation of bone mineral homeostasis, actions critical for a healthy skeleton, vitamin D exerts its influence on many physiologic processes. One of these processes is the immune system. Both the adaptive and innate immune systems are impacted by the active metabolite of vitamin D, 1,25(OH)2D3. In turn, the immune system is now recognized as having a major impact on the skeleton. In this review, I will examine the regulation by 1,25(OH)2D3 of immune function, then examine the evidence for such regulation as potential means of ameliorating the bone loss that accompanies the inflammatory state.


Vitamin D Innate immunity Adaptive immunity Macrophage Keratinocyte Osteoclast 

Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  1. 1.Veterans Affairs Medical Center (111N)San FranciscoUSA

Personalised recommendations