Skeletal Microdamage: Less About Biomechanics and More About Remodeling

  • Matthew R. AllenEmail author
  • David B. Burr
Original Paper


The mechanical consequences of skeletal microdamage have been clearly documented using various experimental methods, yet recent experiments suggest that physiological levels of microdamage accumulation are not sufficient to compromise the bones’ biomechanical properties. While great advances have been made in our understanding of the biomechanical implications of microdamage, less is known concerning the physiological role of microdamage in bone remodeling. Microdamage has been shown to act as a signal for bone remodeling, likely through a disruption of the osteocyte-canalicular network. Interestingly, age-related increases in microdamage are not accompanied by increases in bone remodeling suggesting that the physiological mechanisms which link microdamage and remodeling are compromised with aging.


Microcracks Toughness Targeted remodeling Aging 


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Copyright information

© Humana Press Inc. 2008

Authors and Affiliations

  1. 1.Department of Anatomy and Cell BiologyIndiana University School of MedicineIndianapolisUSA
  2. 2.Department of Orthopaedic SurgeryIndiana University School of MedicineIndianapolisUSA
  3. 3.Department of Biomedical EngineeringIndiana University-Purdue University IndianapolisIndianapolisUSA

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