mTOR Signaling in Parkinson’s Disease
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As a key regulator of cell metabolism and survival, mechanistic target of rapamycin (mTOR) emerges as a novel therapeutic target for Parkinson’s disease (PD). A growing body of research indicates that restoring perturbed mTOR signaling in PD models can prevent neuronal cell death. Nevertheless, molecular mechanisms underlying mTOR-mediated effects in PD have not been fully understood yet. Here, we review recent progress in characterizing the association of mTOR signaling with PD risk factors and further discuss the potential roles of mTOR in PD.
KeywordsmTOR Parkinson’s disease Apoptosis α-Synuclein Oxidative stress
The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (Grant No. 11375213, 21390411) and Hundred Talents Program of the Chinese Academy of Sciences.
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Conflict of interest
The authors declare that they have no conflict of interest.
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