NeuroMolecular Medicine

, Volume 13, Issue 2, pp 160–166 | Cite as

No Association of LOXL1 Gene Polymorphisms with Alzheimer’s Disease

  • Alexandra Abramsson
  • Sara Landgren
  • Madeleine Zetterberg
  • Mona Seibt Palmer
  • Lennart Minthon
  • Deborah R. Gustafson
  • Ingmar Skoog
  • Kaj Blennow
  • Henrik Zetterberg
Original Paper

Abstract

Aggregation of amyloid-beta is one of the major characteristics in brains of patients with Alzheimer’s disease (AD). Although several mechanisms behind the formation of such aggregates have been suggested the regulatory factors are still unknown. The present study aimed at investigating the association of lysyl oxidase-like 1 (LOXL1) polymorphisms with AD diagnosis and cerebrospinal fluid biomarkers (CSF) for the disease. Proteins of the lysyl oxidase (LOX) family are involved in cross-linking extracellular matrix proteins to insoluble fibers and have been associated with neurodegenerative diseases including AD. Genetic polymorphisms in LOXL1 (rs1048661, rs3825942, and rs2165241) have been linked to exfoliation syndrome and exfoliation glaucoma, conditions that have shown association with AD. The polymorphisms were genotyped by Taqman allelic discrimination in a study sample including AD patients (n = 318) and controls (n = 575). In a subgroup of the population, the polymorphisms were analyzed in relation to APOE ε4 genotype and to CSF (T-tau, P-tau, and Aβ1–42). No evidence for associations of these polymorphisms with risk for AD or any of the studied CSF biomarkers measured was found. These results do not support LOXL1 as being a major risk gene for AD.

Keywords

Lysyl oxidase-like 1 LOXL1 Alzheimer’s disease SNP Haplotype 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Alexandra Abramsson
    • 1
  • Sara Landgren
    • 2
  • Madeleine Zetterberg
    • 3
  • Mona Seibt Palmer
    • 1
  • Lennart Minthon
    • 4
  • Deborah R. Gustafson
    • 5
  • Ingmar Skoog
    • 5
  • Kaj Blennow
    • 5
  • Henrik Zetterberg
    • 5
  1. 1.Department of Psychiatry and Neurochemistry, Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of GothenburgGothenburgSweden
  2. 2.Department of Pharmacology, Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of GothenburgGothenburgSweden
  3. 3.Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of GothenburgGothenburgSweden
  4. 4.Clinical Memory Research Unit, Department of Clinical Sciences in MalmöLund UniversityLundSweden
  5. 5.Department of Psychiatry and Neurochemistry, Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of GothenburgMölndalSweden

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