Growth Factors as Mediators of Exercise Actions on the Brain
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Physical exercise has long been recognized as highly beneficial for brain and body health. The molecular mechanisms responsible for translation of exercise stimuli in the brain have claimed attention due to mounting evidence for the neuroprotective actions of the exercise and its positive effects in preventing both ageing and neurodegenerative disease. These molecular mediators are currently under investigation with new tools able to yield deep insights into the neurobiology of exercise. In the present work we focus on the evidence pertaining to the mediation of exercise effects by insulin-like growth factor 1 (IGF1), as recent reports suggest that this growth factor shows brain area-specific, temporal rank-sensitive, and behavioural task-dependent features in response to exercise.
KeywordsInsulin-like growth factor 1 Physical exercise Hippocamus-dependent learning Adult hippocampal neurogenesis Cognitive impairment
- Eliakim, A., Brasel, J. A., & Cooper, D. M. (1999). GH response to exercise: assessment of the pituitary refractory period, and relationship with circulating components of the GH-IGF-I axis in adolescent females. Journal of Pediatric Endocrinology & Metabolism, 12, 47–55.Google Scholar
- Le, G. M., Steensland, P., Le, G. P., et al. (2002). Growth hormone induces age-dependent alteration in the expression of hippocampal growth hormone receptor and N-methyl-D-aspartate receptor subunits gene transcripts in male rats. Proceedings of the National Academy of Sciences of the United States of America, 99, 7119–7123.CrossRefGoogle Scholar
- Shirayama, Y., Chen, A. C., Nakagawa, S., et al. (2002). Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. Journal of Neurosciences, 22, 3251–3261.Google Scholar
- Wallace, J. D., Cuneo, R. C., Baxter, R., et al. (1999). Responses of the growth hormone (GH) and insulin-like growth factor axis to exercise, GH administration, and GH withdrawal in trained adult males: A potential test for GH abuse in sport. The Journal of Clinical Endocrinology and Metabolism, 84, 3591–3601.PubMedCrossRefGoogle Scholar