NeuroMolecular Medicine

, Volume 10, Issue 1, pp 10–16 | Cite as

Nonsynonymous Polymorphisms of Histamine-Metabolising Enzymes in Patients with Parkinson’s Disease

  • José A. G. Agúndez
  • Antonio Luengo
  • Oscar Herráez
  • Carmen Martínez
  • Hortensia Alonso-Navarro
  • Félix Javier Jiménez-Jiménez
  • Elena García-Martín
Original Paper
First Online:
Accepted:

Abstract

Objective    To analyze genetically based impairment in histamine-metabolising enzymes in patients with Parkinson’s disease (PD). Methods    Leukocytary DNA from 214 PD patients and a control group of 295 unrelated healthy individuals was studied for nonsynonymous histamine N-methyltransferase (HNMT) and diamine oxidase (ABP1) polymorphisms by using amplification–restriction analyses. Results    An association of the HNMT Thr105Ile polymorphism, but not of the ABP1 His645Asp polymorphism, with PD was observed. Patients with PD showed a higher frequency of homozygous HNMT genotypes leading to high activity with a gene-dose effect (P < 0.001), as compared to healthy subjects. These findings were independent of gender, but the association with the HNMT polymorphism is higher among patients with late-onset PD (P < 0.0001). Conclusion    These results, combined with previous findings indicating alterations in histamine levels in patients with PD, suggest that alterations of histamine homeostasis in the SNC are associated with the risk for PD.

Keywords

Parkinson’s disease Histamine HNMT DAO ABP1 
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Notes

Acknowledgements

This work was supported in part by Grants SAF 2003–00967 from Ministerio de Ciencia y Tecnología, FIS 05/1056 and 06/1252 from Fondo de Investigación Sanitaria, Instituto de Salud Carlos III.

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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • José A. G. Agúndez
    • 1
  • Antonio Luengo
    • 2
  • Oscar Herráez
    • 1
  • Carmen Martínez
    • 1
  • Hortensia Alonso-Navarro
    • 3
  • Félix Javier Jiménez-Jiménez
    • 3
  • Elena García-Martín
    • 4
  1. 1.Department of Pharmacology & Psychiatry, Medical SchoolUniversity of ExtremaduraBadajozSpain
  2. 2.Service of Neurology University Hospital La PrincesaMadridSpain
  3. 3.Department of Medicine—NeurologyPríncipe de Asturias Hospital, University of Alcalá de HenaresMadridSpain
  4. 4.Department of Biochemistry and Molecular Biology, School of Biological SciencesUniversity of ExtremaduraBadajozSpain

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