Clinical Reviews in Allergy & Immunology

, Volume 55, Issue 1, pp 65–69 | Cite as

Does Aeroallergen Sensitization Cause or Contribute to Eosinophilic Esophagitis?

  • Jesus R. Guajardo
  • Melissa A. Zegarra-Bustamante
  • Edward G. BrooksEmail author


Eosinophilic esophagitis is an atopic disease defined clinically by esophageal symptoms in combination with a dense esophageal eosinophilia. EoE is triggered and maintained by exposure to certain foods and it is known that dietary modification controls symptoms and achieves disease remission. Recently, aeroallergens have been implicated in the pathogenesis of EoE. To examine the role of aeroallergens in EoE, we reviewed the published literature. Sensitization and production of IgE antibodies to foods and aeroallergens in subjects with EoE has been demonstrated. However, the evidence suggests only a minor role for IgE-mediated immune reactions in EoE. There is some evidence to support an association of EoE diagnosis and flares with environmental allergen exposure, and animal studies support the notion that EoE may be induced by exposure to inhalant allergens. Some studies show that newly diagnosed cases of EoE follow a seasonal pollen distribution (summer and spring), but the weight of evidence does not support the seasonal occurrence of diagnosis or worsening of symptoms. Overall, we conclude that the current evidence does not support causality in inhalant allergen exposure and the genesis nor exacerbations of EoE in humans, although there is a possibility that inhalant allergen sensitization could play a modifying role in EoE in the context of cross-reacting food allergens.


Eosinophilic esophagitis Aeroallergen Pollen Cross-reactivity 



eosinophilic esophagitis


skin prick test


sub-lingual immunotherapy


oral allergy syndrome


atopy patch test


pathogenesis related


component-resolved diagnosis


Compliance with Ethical Standards

Conflict of Interest

JRG and MAZ-B declare that they have no conflict of interest. EGB has received a research contract from ALK-Abello investigating allergen T cell epitopes and serves on the Scientific Advisory Board for United Allergy Services.

Research Involving Human Participants and/or Animals

There is no research involving humans or animals

Informed Consent

No human research.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Jesus R. Guajardo
    • 1
  • Melissa A. Zegarra-Bustamante
    • 2
  • Edward G. Brooks
    • 2
    Email author
  1. 1.Division of Pulmonary Medicine, Department of PediatricsUT Health San AntonioSan AntonioUSA
  2. 2.Division of Immunology and Infectious Disease, Department of PediatricsUT Health San AntonioSan AntonioUSA

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