Clinical Reviews in Allergy & Immunology

, Volume 53, Issue 3, pp 371–393 | Cite as

Skin Manifestations of Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Spondyloarthritides

  • Carolyn Jean Chua-Aguilera
  • Burkhard Möller
  • Nikhil YawalkarEmail author


Extra-articular manifestations of rheumatoid arthritis, juvenile idiopathic arthritis, and various spondyloarthritides including psoriatic arthritis, ankylosing spondylitis, reactive arthritis, and inflammatory bowel disease-associated spondyloarthritis often involve the skin and may occur before or after diagnosis of these rheumatic diseases. Cutaneous manifestations encompass a wide range of reactions that may have a notable negative impact not only on the physical but especially on the emotional and psychosocial well-being of these patients. Several cutaneous manifestations have been related to rheumatoid arthritis such as subcutaneous nodules including classical rheumatoid nodules, accelerated rheumatoid nodulosis, and rheumatoid nodulosis; vascular disorders like rheumatoid vasculitis, livedo racemosa, and Raynaud’s phenomenon; and neutrophilic and/or granulomatous diseases like pyoderma gangrenosum, Sweet’s syndrome, rheumatoid neutrophilic dermatitis, interstitial granulomatous dermatitis with arthritis, as well as palisaded neutrophilic and granulomatous dermatitis. In juvenile idiopathic arthritis, the main cutaneous manifestations include an evanescent rash, rheumatoid nodules, as well as plaque and guttate psoriasis. Plaque psoriasis is also the main skin disease involved in spondyloarthritides. Furthermore, other forms of psoriasis including guttate, inverse, erythrodermic, pustular, and particularly nail psoriasis may also occur. In addition, a variety of drug-induced skin reactions may also appear in these diseases. Early recognition and understanding of these different dermatologic manifestations together with an interdisciplinary approach are often needed to optimize management of these diseases.


Rheumatoid arthritis Juvenile idiopathic arthritis Spondyloarthritis Psoriasis Inflammatory bowel disease DMARDs 



Rheumatoid arthritis


Rheumatoid factor


Human leukocyte antigen


Disease modifying anti-rheumatic drugs




Tumor necrosis factor


Rheumatoid vasculitis


Neutrophilic dermatoses


Rheumatoid neutrophilic dermatitis


Pyoderma gangrenosum


Polymorphonuclear leucocytes


Cluster of differentiation


Non-steroidal anti-inflammatory drugs


Palisaded neutrophilic and granulomatous dermatitis


Juvenile idiopathic arthritis


Macrophage activation syndrome


T helper 1 cell


Generalized pustular psoriasis


Acute generalized exanthematous pustulosis


Palmoplantar pustulosis


Potassium hydroxide test


Venereal disease research laboratory test


Reactive arthritis


Inflammatory bowel disease


Ulcerative colitis


Synovitis, acne, pustulosis, hyperostosis, and osteitis


Compliance with Ethical Standards

Conflict of Interest

Carolyn Jean Chua-Aguilera, Burkhard Möller, and Nikhil Yawalkar declare that they have no conflict of interest.



Ethical Approval

Not applicable.

Informed Consent

Not applicable.


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© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Department of Dermatology, Inselspital, Bern University HospitalUniversity of BernBernSwitzerland
  2. 2.Department for Rheumatology, Immunology and Allergology, Inselspital, Bern University HospitalUniversity of BernBernSwitzerland

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