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Clinical Reviews in Allergy & Immunology

, Volume 50, Issue 2, pp 228–239 | Cite as

Eosinophilic Drug Allergy

  • Merin Kuruvilla
  • David A. KhanEmail author
Article

Abstract

While peripheral or tissue eosinophilia may certainly characterize drug eruptions, this feature is hardly pathognomonic for a medication-induced etiology. While delayed drug hypersensitivity reactions with prominent eosinophilic recruitment have been typically classified as type IVb reactions, their pathophysiology is now known to be more complex. Eosinophilic drug reactions have a diversity of presentations and may be benign and self-limited to severe and life-threatening. The extent of clinical involvement is also heterogeneous, ranging from isolated peripheral eosinophilia or single organ involvement (most often the skin and lung) to systemic disease affecting multiple organs, classically exemplified by drug-reaction with eosinophilia and systemic symptoms (DRESS). The spectrum of implicated medications in the causation of DRESS is ever expanding, and multiple factors including drug metabolites, specific HLA alleles, herpes viruses, and immune system activation have been implicated in pathogenesis. Due to this complex interplay of various factors, diagnostic workup in terms of skin and laboratory testing has not been validated. Similarly, the lack of controlled trials limits treatment options. This review also describes other localized as well as systemic manifestations of eosinophilic disease induced by various medication classes, including their individual pathophysiology, diagnosis, and management. Given the multitude of clinical patterns associated with eosinophilic drug allergy, the diagnosis can be challenging. Considerable deficits in our knowledge of these presentations remain, but the potential for severe reactions should be borne in mind in order to facilitate diagnosis and institute appropriate management.

Keywords

Drug allergy Eosinophilia Drug-reaction with eosinophilia and systemic symptoms (DRESS) Eosinophilic pneumonia Drug exanthema Aspirin-exacerbated respiratory disease 

References

  1. 1.
    Romagosa R, Kapoor S, Sanders J, Berman B (2001) Inpatient adverse cutaneous drug eruptions and eosinophilia. Arch Dermatol 137(4):511–512PubMedGoogle Scholar
  2. 2.
    Gerson D, Sriganeshan V, Alexis JB (2008) Cutaneous drug eruptions: a 5-year experience. J Am Acad Dermatol 59(6):995–999PubMedCrossRefGoogle Scholar
  3. 3.
    Seitz CS, Rose C, Kerstan A, Trautmann A (2013) Drug-induced exanthems: correlation of allergy testing with histologic diagnosis. J Am Acad Dermatol 69(5):721–728PubMedCrossRefGoogle Scholar
  4. 4.
    Pichler WJ (2003) Delayed drug hypersensitivity reactions. Ann Intern Med 139(8):683–693PubMedCrossRefGoogle Scholar
  5. 5.
    Yawalkar N, Shrikhande M, Hari Y, Nievergelt H et al (2000) Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug-induced cutaneous eruptions. J Allergy Clin Immunol 106(6):1171–1176PubMedCrossRefGoogle Scholar
  6. 6.
    Yang J, Yang X, Li M (2013) Peripheral blood eosinophil counts predict the prognosis of drug eruptions. J Investig Allergol Clin Immunol 23(4):248–255PubMedGoogle Scholar
  7. 7.
    Tefferi A, Patnaik MM, Pardanani A (2006) Eosinophilia: secondary, clonal and idiopathic. Br J Haematol 133(5):468–492PubMedCrossRefGoogle Scholar
  8. 8.
    Garcia M, Ruiz B, Aguirre C, Etxegerai E et al (2013) Eosinophilia associated with bupropion. Int J Clin Pharm 35(4):532–534PubMedCrossRefGoogle Scholar
  9. 9.
    Quaglino P, Bergallo M, Ponti R, Barberio E et al (2011) Th1, Th2, Th17 and regulatory T cell pattern in psoriatic patients: modulation of cytokines and gene targets induced by etanercept treatment and correlation with clinical response. Dermatology 223(1):57–67PubMedCrossRefGoogle Scholar
  10. 10.
    Malisiewicz B, Murer C, Pachlopnik Schmid J, French LE et al (2011) Eosinophilia during psoriasis treatment with TNF antagonists. Dermatology 223(4):311–315PubMedCrossRefGoogle Scholar
  11. 11.
    Woessner KM, Castells M (2013) NSAID single-drug-induced reactions. Immunol Allergy Clin North Am 33(2):237–249PubMedCrossRefGoogle Scholar
  12. 12.
    Alkhateeb H, Said S, Cooper CJ, Gaur S et al (2013) DRESS syndrome following ciprofloxacin exposure: an unusual association. Am J Case Rep 14:526–528PubMedPubMedCentralCrossRefGoogle Scholar
  13. 13.
    Leao RN, Barreto P, Leao RR, Ribeiro JV (2013) Nitrofurantoin: cause of DRESS syndrome. BMJ Case Rep 2013Google Scholar
  14. 14.
    Savard S, Desmeules S, Riopel J, Agharazii M (2009) Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome. Am J Kidney Dis 54(6):e17–e20PubMedCrossRefGoogle Scholar
  15. 15.
    Kaswala DH (2013) Drug rash with eosinophilia and systemic symptoms syndrome due to anti-TB medication. J Family Med Prim Care 2(1):83–85PubMedPubMedCentralCrossRefGoogle Scholar
  16. 16.
    Bensaid B, Rozieres A, Nosbaum A, Nicolas JF et al (2012) Amikacin-induced drug reaction with eosinophilia and systemic symptoms syndrome: delayed skin test and ELISPOT assay results allow the identification of the culprit drug. J Allergy Clin Immunol 130(6):1413–1414PubMedCrossRefGoogle Scholar
  17. 17.
    Chang YS (2012) Hypersensitivity reactions to proton pump inhibitors. Curr Opin Allergy Clin Immunol 12(4):348–353PubMedCrossRefGoogle Scholar
  18. 18.
    Galvao VR, Aun MV, Kalil J, Castells M et al (2014) Clinical and laboratory improvement after intravenous immunoglobulin in drug reaction with eosinophilia and systemic symptoms. J Allergy Clin Immunol Pract 2(1):107–110PubMedCrossRefGoogle Scholar
  19. 19.
    Pinto B, Dhir V, Krishnan S, Nada R (2013) Leflunomide-induced DRESS syndrome with renal involvement and vasculitis. Clin Rheumatol 32(5):689–693PubMedCrossRefGoogle Scholar
  20. 20.
    Saunderson RB, Garsia R, Headley AP, McCaughan GW et al (2013) Pentoxifylline-induced drug rash with eosinophilia and systemic symptoms (DRESS) in a patient with caffeine intolerance. J Dermatol Case Rep 7(3):77–81PubMedPubMedCentralCrossRefGoogle Scholar
  21. 21.
    Ghislain PD, Bodarwe AD, Vanderdockt O, Tennstedt D et al (2004) Drug-induced eosinophilia and multisystemic failure with positive patch-test reaction to spironolactone: DRESS syndrome. Acta Derm Venereol 84(1):65–68PubMedCrossRefGoogle Scholar
  22. 22.
    Ronceray S, Dinulescu M, Le Gall F, Polard E et al (2012) Enoxaparin-induced DRESS syndrome. Case Rep Dermatol 4(3):233–237PubMedPubMedCentralCrossRefGoogle Scholar
  23. 23.
    Sin C, Mahe E, Sigal ML (2012) Drug reaction with eosinophilia and systemic symptoms (DRESS) in a patient taking sitagliptin. Diabetes Metab 38(6):571–573PubMedCrossRefGoogle Scholar
  24. 24.
    Jonville-Bera AP, Crickx B, Aaron L, Hartingh I et al (2009) Strontium ranelate-induced DRESS syndrome: first two case reports. Allergy 64(4):658–659PubMedCrossRefGoogle Scholar
  25. 25.
    Choudhary S, McLeod M, Torchia D, Romanelli P (2013) Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. J Clin Aesthet Dermatol 6(6):31–37Google Scholar
  26. 26.
    Pavlos R, Mallal S, Ostrov D, Pompeu Y et al (2014) Fever, rash, and systemic symptoms: understanding the role of virus and HLA in severe cutaneous drug allergy. J Allergy Clin Immunol Pract 2(1):21–33PubMedPubMedCentralCrossRefGoogle Scholar
  27. 27.
    Chung WH, Hung SI, Hong HS, Hsih MS et al (2004) Medical genetics: a marker for Stevens-Johnson syndrome. Nature 428(6982):486PubMedCrossRefGoogle Scholar
  28. 28.
    McCormack M, Alfirevic A, Bourgeois S, Farrell JJ et al (2011) HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med 364(12):1134–1143PubMedPubMedCentralCrossRefGoogle Scholar
  29. 29.
    Saag M, Balu R, Phillips E, Brachman P et al (2008) High sensitivity of human leukocyte antigen-b*5701 as a marker for immunologically confirmed abacavir hypersensitivity in white and black patients. Clin Infect Dis 46(7):1111–1118PubMedCrossRefGoogle Scholar
  30. 30.
    Adam J, Wuilleman N, Watkins S, Jamin H et al (2014) Abacavir induced T cell reactivity from drug naive individuals shares features of allo-immune responses. PLoS One 9(4), e95339PubMedPubMedCentralCrossRefGoogle Scholar
  31. 31.
    Kano Y, Shiohara T (2004) Sequential reactivation of herpesvirus in drug-induced hypersensitivity syndrome. Acta Derm Venereol 84(6):484–485PubMedGoogle Scholar
  32. 32.
    Aihara Y, Ito SI, Kobayashi Y, Yamakawa Y et al (2003) Carbamazepine-induced hypersensitivity syndrome associated with transient hypogammaglobulinaemia and reactivation of human herpesvirus 6 infection demonstrated by real-time quantitative polymerase chain reaction. Br J Dermatol 149(1):165–169PubMedCrossRefGoogle Scholar
  33. 33.
    Huang YC, Shih PY, Chin SY, Chiang YY (2012) Allopurinol-induced drug rash with eosinophilia and systemic symptoms mimicking acute generalized exanthematous pustulosis. J Dermatol 39(12):1077–1078PubMedCrossRefGoogle Scholar
  34. 34.
    Cacoub P, Musette P, Descamps V, Meyer O et al (2011) The DRESS syndrome: a literature review. Am J Med 124(7):588–597PubMedCrossRefGoogle Scholar
  35. 35.
    Morito H, Ogawa K, Fukumoto T, Kobayashi N et al (2014) Increased ratio of FoxP3+ regulatory T cells/CD3+ T cells in skin lesions in drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms. Clin Exp Dermatol 39(3):284–291PubMedCrossRefGoogle Scholar
  36. 36.
    Lee T, Lee YS, Yoon SY, Kim S et al (2013) Characteristics of liver injury in drug-induced systemic hypersensitivity reactions. J Am Acad Dermatol 69(3):407–415PubMedCrossRefGoogle Scholar
  37. 37.
    O’Meara P, Borici-Mazi R, Morton AR, Ellis AK (2011) DRESS with delayed onset acute interstitial nephritis and profound refractory eosinophilia secondary to Vancomycin. Allergy Asthma Clin Immunol 7:16PubMedPubMedCentralCrossRefGoogle Scholar
  38. 38.
    Coban-Karatas M, Turunc T, Altan-Yaycioglu R (2012) Purtscher-like retinopathy related to drug-induced hypersensitivity syndrome. Ocul Immunol Inflamm 20(6):475–477PubMedCrossRefGoogle Scholar
  39. 39.
    Kardaun SH, Sekula P, Valeyrie-Allanore L, Liss Y et al (2013) Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study. Br J Dermatol 169(5):1071–1080PubMedCrossRefGoogle Scholar
  40. 40.
    Peyriere H, Dereure O, Breton H, Demoly P et al (2006) Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol 155(2):422–428PubMedCrossRefGoogle Scholar
  41. 41.
    Kano Y, Shiohara T (2010) Visceral involvements and long-term sequelae in drug-induced hypersensitivity syndrome. Med Clin North Am 94(4):743–759, xi PubMedCrossRefGoogle Scholar
  42. 42.
    Choquet-Kastylevsky G, Intrator L, Chenal C, Bocquet H et al (1998) Increased levels of interleukin 5 are associated with the generation of eosinophilia in drug-induced hypersensitivity syndrome. Br J Dermatol 139(6):1026–1032PubMedCrossRefGoogle Scholar
  43. 43.
    Ogawa K, Morito H, Hasegawa A, Daikoku N et al (2013) Identification of thymus and activation-regulated chemokine (TARC/CCL17) as a potential marker for early indication of disease and prediction of disease activity in drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS). J Dermatol Sci 69(1):38–43PubMedCrossRefGoogle Scholar
  44. 44.
    Nishio D, Izu K, Kabashima K, Tokua Y (2007) T cell populations propagating in the peripheral blood of patients with drug eruptions. J Dermatol Sci 48(1):25–33PubMedCrossRefGoogle Scholar
  45. 45.
    Picard D, Janela B, Descamps V, D’Incan M et al (2010) Drug reaction with eosinophilia and systemic symptoms (DRESS): a multiorgan antiviral T cell response. Sci Transl Med 2(46):46ra62PubMedCrossRefGoogle Scholar
  46. 46.
    Yoshikawa T, Fujita A, Yagami A, Suzuki K et al (2006) Human herpesvirus 6 reactivation and inflammatory cytokine production in patients with drug-induced hypersensitivity syndrome. J Clin Virol 37(Suppl 1):S92–S96PubMedCrossRefGoogle Scholar
  47. 47.
    Barbaud A (2005) Drug patch testing in systemic cutaneous drug allergy. Toxicology 209(2):209–216PubMedCrossRefGoogle Scholar
  48. 48.
    Barbaud A, Collet E, Milpied B, Assier H et al (2013) A multicentre study to determine the value and safety of drug patch tests for the three main classes of severe cutaneous adverse drug reactions. Br J Dermatol 168(3):555–562PubMedCrossRefGoogle Scholar
  49. 49.
    Phatharacharukul P, Klaewsongkram J (2013) A case of sulfasalazine-induced hypersensitivity syndrome confirmed by enzyme-linked immunospot assay. Allergy Asthma Immunol Res 5(6):415–417PubMedPubMedCentralCrossRefGoogle Scholar
  50. 50.
    Beeler A, Engler O, Gerber BO, Pichler WJ (2006) Long-lasting reactivity and high frequency of drug-specific T cells after severe systemic drug hypersensitivity reactions. J Allergy Clin Immunol 117(2):455–462PubMedCrossRefGoogle Scholar
  51. 51.
    Daubner B, Groux-Keller M, Hausmann OV, Kawabata T et al (2012) Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells. Allergy 67(1):58–66PubMedCrossRefGoogle Scholar
  52. 52.
    Shiohara T, Inaoka M, Kano Y (2006) Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses. Allergol Int 55(1):1–8PubMedCrossRefGoogle Scholar
  53. 53.
    Picard D, Vellar M, Janela B, Roussel A, et al (2014) Recurrence of drug-induced reactions in DRESS patients. J Eur Acad Dermatol VenereolGoogle Scholar
  54. 54.
    Joly P, Janela B, Tetart F, Rogez S et al (2012) Poor benefit/risk balance of intravenous immunoglobulins in DRESS. Arch Dermatol 148(4):543–544PubMedCrossRefGoogle Scholar
  55. 55.
    Ushigome Y, Kano Y, Ishida T, Hirahara K et al (2013) Short- and long-term outcomes of 34 patients with drug-induced hypersensitivity syndrome in a single institution. J Am Acad Dermatol 68(5):721–728PubMedCrossRefGoogle Scholar
  56. 56.
    Chen YC, Chang CY, Cho YT, Chiu HC et al (2013) Long-term sequelae of drug reaction with eosinophilia and systemic symptoms: a retrospective cohort study from Taiwan. J Am Acad Dermatol 68(3):459–465PubMedCrossRefGoogle Scholar
  57. 57.
    Takahashi R, Kano Y, Yamazaki Y, Kimishima M et al (2009) Defective regulatory T cells in patients with severe drug eruptions: timing of the dysfunction is associated with the pathological phenotype and outcome. J Immunol 182(12):8071–8079PubMedCrossRefGoogle Scholar
  58. 58.
    Oddo M, Liaudet L, Lepori M, Broccard AF et al (2003) Relapsing acute respiratory failure induced by minocycline. Chest 123(6):2146–2148PubMedCrossRefGoogle Scholar
  59. 59.
    Kim PW, Sorbello AF, Wassel RT, Pham TM et al (2012) Eosinophilic pneumonia in patients treated with daptomycin: review of the literature and US FDA adverse event reporting system reports. Drug Saf 35(6):447–457PubMedCrossRefGoogle Scholar
  60. 60.
    Saha K, Bandyopadhyay A, Sengupta A, Jash D (2013) A rare case of ethambutol induced pulmonary eosinophilia. J Pharmacol Pharmacother 4(4):300–302PubMedPubMedCentralCrossRefGoogle Scholar
  61. 61.
    Just N, Carpentier O, Brzezinki C, Steenhouwer F et al (2011) Severe hypersensitivity reaction as acute eosinophilic pneumonia and skin eruption induced by proguanil. Eur Respir J 37(6):1526–1528PubMedCrossRefGoogle Scholar
  62. 62.
    Lee SP, Kim SH, Kim TH, Sohn JW et al (2010) A case of mexiletine-induced hypersensitivity syndrome presenting as eosinophilic pneumonia. J Korean Med Sci 25(1):148–151PubMedPubMedCentralCrossRefGoogle Scholar
  63. 63.
    Adar T, Tayer-Shifman O, Mizrahi M, Tavdi S et al (2012) Dapsone induced eosinophilic pneumonia. Eur Ann Allergy Clin Immunol 44(3):144–146PubMedGoogle Scholar
  64. 64.
    Poland GA, Love KR (1986) Marked atypical lymphocytosis, hepatitis, and skin rash in sulfasalazine drug allergy. Am J Med 81(4):707–708PubMedCrossRefGoogle Scholar
  65. 65.
    Tsigkaropoulou E, Hatzilia D, Rizos E, Christodoulou C et al (2011) Venlafaxine-induced acute eosinophilic pneumonia. Gen Hosp Psychiatry 33(4):411 e7–9PubMedCrossRefGoogle Scholar
  66. 66.
    Rizos E, Tsigkaropoulou E, Lambrou P, Kanakaki M et al (2013) Risperidone-induced acute eosinophilic pneumonia. In Vivo 27(5):651–653PubMedGoogle Scholar
  67. 67.
    Cottin V, Cordier JF (2012) Eosinophilic lung diseases. Immunol Allergy Clin North Am 32(4):557–586PubMedCrossRefGoogle Scholar
  68. 68.
    Allen JN (2004) Drug-induced eosinophilic lung disease. Clin Chest Med 25(1):77–88PubMedCrossRefGoogle Scholar
  69. 69.
    Bullington W, Sahn SA, Judson MA (2007) Valproic acid-induced eosinophilic pleural effusion: a case report and review of the literature. Am J Med Sci 333(5):290–292PubMedCrossRefGoogle Scholar
  70. 70.
    Behnia M, Dowdeswell I, Vakili S (2000) Pleural fluid and serum eosinophilia: association with fluoxetine hydrochloride. South Med J 93(6):611–613PubMedCrossRefGoogle Scholar
  71. 71.
    Raptis L, Pappas G, Katsanou A, Koutsouka F et al (2007) Diltiazem-induced eosinophilic pleural effusion. Pharmacotherapy 27(4):600–602PubMedCrossRefGoogle Scholar
  72. 72.
    Patel JJ, Lisi PA, Lathara Z, Lipchik RJ (2012) Clozapine-induced peripheral and pleural fluid eosinophilia. Ann Pharmacother 46(2):e4PubMedCrossRefGoogle Scholar
  73. 73.
    Abdelhamid MS, Percival M, Sivakumaran P (2011) Sodium valproate—a rare cause of eosinophilic pleural effusion. Intern Med J 41(11):802–803PubMedCrossRefGoogle Scholar
  74. 74.
    King BA, Geelhoed GC (2003) Adverse skin and joint reactions associated with oral antibiotics in children: the role of cefaclor in serum sickness-like reactions. J Paediatr Child Health 39(9):677–681PubMedCrossRefGoogle Scholar
  75. 75.
    Finger E, Scheinberg M (2007) Development of serum sickness-like symptoms after rituximab infusion in two patients with severe hypergammaglobulinemia. J Clin Rheumatol 13(2):94–95PubMedCrossRefGoogle Scholar
  76. 76.
    Bircher AJ, Scherer K (2010) Delayed cutaneous manifestations of drug hypersensitivity. Med Clin North Am 94(4):711–725, x PubMedCrossRefGoogle Scholar
  77. 77.
    Mikami C, Ochiai K, Umemiya K, Matsumura R et al (1999) Eosinophil activation and in situ interleukin-5 production by mononuclear cells in skin lesions of patients with drug hypersensitivity. J Dermatol 26(10):633–639PubMedCrossRefGoogle Scholar
  78. 78.
    Ferguson NN, Asarch A, VanBeek M, Swick BL (2013) Acute mucocutaneous methotrexate toxicity associated with interface dermatitis and numerous eosinophils. Am J Dermatopathol 35(4):e63–e66PubMedCrossRefGoogle Scholar
  79. 79.
    Schaffellner S, Jakoby E, Kneipeiss D, Stadlbauer V et al (2005) Center experience in liver transplantation (LTX): management of dermal side effects caused by sirolimus. Int Immunopharmacol 5(1):137–140PubMedCrossRefGoogle Scholar
  80. 80.
    Gandhi M, Kuzel T, Lacouture M (2009) Eosinophilic rash secondary to temsirolimus. Clin Genitourin Cancer 7(2):E34–E36PubMedCrossRefGoogle Scholar
  81. 81.
    Bircher AJ, Scherer K (2006) Hypersensitivity reactions to anticoagulant drugs: diagnosis and management options. Allergy 61(12):1432–1440PubMedCrossRefGoogle Scholar
  82. 82.
    Klos K, Spiewak R, Kruszewski J, Bant A (2011) Cutaneous adverse drug reaction to heparins with hypereosinophilia and high IgE level. Contact Dermatitis 64(1):61–62PubMedCrossRefGoogle Scholar
  83. 83.
    Sidoroff A, Dunant A, Viboud C, Halevy S et al (2007) Risk factors for acute generalized exanthematous pustulosis (AGEP)-results of a multinational case-control study (EuroSCAR). Br J Dermatol 157(5):989–996PubMedCrossRefGoogle Scholar
  84. 84.
    Machet L, Martin L, Vaillant L (2001) Acute generalized exanthematic pustulosis. Ann Dermatol Venereol 128(1):73–79PubMedGoogle Scholar
  85. 85.
    Laing ME, Laing TA, Mulligan NJ, Keane FM (2006) Eosinophilic pustular folliculitis induced by chemotherapy. J Am Acad Dermatol 54(4):729–730PubMedCrossRefGoogle Scholar
  86. 86.
    Mizoguchi S, Setoyama M, Higashi Y, Hozumi H et al (1998) Eosinophilic pustular folliculitis induced by carbamazepine. J Am Acad Dermatol 38(4):641–643PubMedCrossRefGoogle Scholar
  87. 87.
    Ooi CG, Walker P, Sidhu SK, Gordon LA et al (2006) Allopurinol induced generalized eosinophilic pustular folliculitis. Australas J Dermatol 47(4):270–273PubMedCrossRefGoogle Scholar
  88. 88.
    Laga AC, Vleugels RA, Qureshi AA, Velazquez EF (2010) Histopathologic spectrum of psoriasiform skin reactions associated with tumor necrosis factor-alpha inhibitor therapy. A study of 16 biopsies. Am J Dermatopathol 32(6):568–573PubMedCrossRefGoogle Scholar
  89. 89.
    Choi TS, Doh KS, Kim SH, Jang MS et al (2003) Clinicopathological and genotypic aspects of anticonvulsant-induced pseudolymphoma syndrome. Br J Dermatol 148(4):730–736PubMedCrossRefGoogle Scholar
  90. 90.
    Tugnet N, Youssef A, Whallett AJ (2012) Wells’ syndrome (eosinophilic cellulitis) secondary to infliximab. Rheumatology (Oxford) 51(1):195–196CrossRefGoogle Scholar
  91. 91.
    Boura P, Sarantopoulos A, Lefaki I, Skendros P et al (2006) Eosinophilic cellulitis (Wells’ syndrome) as a cutaneous reaction to the administration of adalimumab. Ann Rheum Dis 65(6):839–840PubMedPubMedCentralCrossRefGoogle Scholar
  92. 92.
    Winfield H, Lain E, Horn T, Hoskyn J (2006) Eosinophilic cellulitis like reaction to subcutaneous etanercept injection. Arch Dermatol 142(2):218–220PubMedCrossRefGoogle Scholar
  93. 93.
    Choquet-Kastylevsky G, Kanitakis J, Dumas V, Descotes J et al (2001) Eosinophilic fasciitis and simvastatin. Arch Intern Med 161(11):1456–1457PubMedCrossRefGoogle Scholar
  94. 94.
    DeGiovanni C, Chard M, Woollons A (2006) Eosinophilic fasciitis secondary to treatment with atorvastatin. Clin Exp Dermatol 31(1):131–132PubMedCrossRefGoogle Scholar
  95. 95.
    Buchanan RR, Gordon DA, Muckle TJ, McKenna F et al (1980) The eosinophilic fasciitis syndrome after phenytoin (dilantin) therapy. J Rheumatol 7(5):733–736PubMedGoogle Scholar
  96. 96.
    Baldwin DS, Levine BB, McCluskey RT, Gallo GR (1968) Renal failure and interstitial nephritis due to penicillin and methicillin. N Engl J Med 279(23):1245–1252PubMedCrossRefGoogle Scholar
  97. 97.
    Baker RJ, Pusey CD (2004) The changing profile of acute tubulointerstitial nephritis. Nephrol Dial Transplant 19(1):8–11PubMedCrossRefGoogle Scholar
  98. 98.
    Beghetti M, Wilson GJ, Bohn D, Benson L (1998) Hypersensitivity myocarditis caused by an allergic reaction to cefaclor. J Pediatr 132(1):172–173PubMedCrossRefGoogle Scholar
  99. 99.
    Chikwava KR, Savell VH Jr, Boyd TK (2006) Fatal cephalosporin-induced acute hypersensitivity myocarditis. Pediatr Cardiol 27(6):777–780PubMedCrossRefGoogle Scholar
  100. 100.
    Haas SJ, Hill R, Krum H, Liew D et al (2007) Clozapine-associated myocarditis: a review of 116 cases of suspected myocarditis associated with the use of clozapine in Australia during 1993–2003. Drug Saf 30(1):47–57PubMedCrossRefGoogle Scholar
  101. 101.
    Kanai-Yoshizawa S, Sugiyama Kato T, Mancini D, Marboe CC (2013) Hypersensitivity myocarditis and outcome after heart transplantation. J Heart Lung Transplant 32(5):553–559PubMedCrossRefGoogle Scholar
  102. 102.
    Fix OK, Peters MG, Davern TJ (2006) Eosinophilic hepatitis caused by lamotrigine. Clin Gastroenterol Hepatol 4(4):26CrossRefGoogle Scholar
  103. 103.
    Hood B, Nowicki MJ (2010) Eosinophilic hepatitis in an adolescent during lisdexamfetamine dimesylate treatment for ADHD. Pediatrics 125(6):e1510–e1513PubMedCrossRefGoogle Scholar
  104. 104.
    Saeed SA, Integlia MJ, Pleskow RG, Calenda KA et al (2006) Tacrolimus-associated eosinophilic gastroenterocolitis in pediatric liver transplant recipients: role of potential food allergies in pathogenesis. Pediatr Transplant 10(6):730–735PubMedCrossRefGoogle Scholar
  105. 105.
    Atkinson RJ, Dennis G, Cross SS, McAlindon ME et al (2004) Eosinophilic colitis complicating anti-epileptic hypersensitivity syndrome: an indication for colonoscopy? Gastrointest Endosc 60(6):1034–1036PubMedCrossRefGoogle Scholar
  106. 106.
    Lange P, Oun H, Fuller S, Turney JH (1994) Eosinophilic colitis due to rifampicin. Lancet 344(8932):1296–1297PubMedCrossRefGoogle Scholar
  107. 107.
    Tsakiri A, Balslev I, Klarskov P (2004) Eosinophilic cystitis induced by penicillin. Int Urol Nephrol 36(2):159–161PubMedCrossRefGoogle Scholar
  108. 108.
    Bansal S, Gupta M, Sharma D, Bansal S (2014) A rare case of Ibuprofen-induced eosinophilic meningitis in a 13-year-old girl. Clin Med Insights Pediatr 8:3–4PubMedPubMedCentralGoogle Scholar
  109. 109.
    Asperilla MO, Smego RA Jr (1989) Eosinophilic meningitis associated with ciprofloxacin. Am J Med 87(5):589–590PubMedCrossRefGoogle Scholar
  110. 110.
    Grabb PA, Albright AL (1992) Intraventricular vancomycin-induced cerebrospinal fluid eosinophilia: report of two patients. Neurosurgery 30(4):630–634Google Scholar
  111. 111.
    Bell RS, Vo AH, Cooper PB, Schmitt CL et al (2006) Eosinophilic meningitis after implantation of a rifampin and minocycline-impregnated ventriculostomy catheter in a child. Case Report J Neurosurg 104(1 Suppl):50–54PubMedGoogle Scholar
  112. 112.
    Bochenek G, Nizankowska-Mogilnicka E (2013) Aspirin-exacerbated respiratory disease: clinical disease and diagnosis. Immunol Allergy Clin North Am 33(2):147–161PubMedCrossRefGoogle Scholar
  113. 113.
    Narayanankutty A, Resendiz-Hernandez JM, Falfan-Valencia R, Teran LM (2013) Biochemical pathogenesis of aspirin exacerbated respiratory disease (AERD). Clin Biochem 46(7–8):566–578PubMedCrossRefGoogle Scholar
  114. 114.
    James A, Daham K, Backman L, Brunnstrom A et al (2013) The influence of aspirin on release of eoxin C4, leukotriene C4 and 15-HETE, in eosinophilic granulocytes isolated from patients with asthma. Int Arch Allergy Immunol 162(2):135–142PubMedCrossRefGoogle Scholar
  115. 115.
    Yoo HS, Shin YS, Liu JN, Kim MA et al (2013) Clinical significance of immunoglobulin E responses to staphylococcal superantigens in patients with aspirin-exacerbated respiratory disease. Int Arch Allergy Immunol 162(4):340–345PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Internal Medicine, Division of Allergy & ImmunologyUniversity of Texas Southwestern Medical CenterDallasUSA

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