Clinical Reviews in Allergy & Immunology

, Volume 50, Issue 2, pp 252–272

Biological Modulators in Eosinophilic Diseases



Eosinophils can regulate local and systemic inflammation, and their presence in higher numbers appears to play an important role in the pathology of various atopic and inflammatory diseases. Eosinophil maturation, recruitment, and survival depend on several cytokine regulators, including interleukin (IL)-5, IL-4, and IL-13 as well as growth factors such as GM-CSF. Over the last decade, the approach to treating eosinophilic diseases has changed greatly. A number of biologic modulators have been developed to target eosinophilic inflammatory pathways, and their usage has resulted in variable clinical improvement in the treatment of eosinophilic-associated conditions. Novel targeted therapies that are safe and effective for treating these disorders are being investigated. This review summarizes the clinical use of biologic agents that have been studied in clinical trials or approved for treating eosinophilic diseases.


Eosinophils Eosinophilic diseases Biologics Monoclonal antibodies Asthma Hypereosinophilic syndrome Eosinophilic granulomatosis with polyangiitis Churg-Strauss syndrome Nasal polyposis Eosinophilic esophagitis 



Monoclonal antibody


Hypereosinophilic syndrome


Complete hematologic response


Complete molecular response


Churg-Strauss syndrome


Eosinophilic granulomatosis with polyangiitis


Nasal polyposis


Eosinophilic esophagitis


Chemoattractant receptor homologous molecule expressed on Th2 cells


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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Division of Allergy, Immunology, and Rheumatology, Department of PediatricsUniversity of South FloridaSt. PetersburgUSA

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