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Clinical Reviews in Allergy & Immunology

, Volume 44, Issue 3, pp 229–241 | Cite as

Traditional Chinese Medicine and Immune Regulation

  • Hong-Di Ma
  • Yan-Ru Deng
  • Zhigang Tian
  • Zhe-Xiong LianEmail author
Article

Abstract

Traditional Chinese medicines (TCMs) have a long history in Asian countries and are traditionally used to prevent and treat a variety of diseases. The rising interest in TCMs in recent years is reflected in both the increase in their market demand as well as scientific research. Previous studies show that TCMs perform dual roles on immunological regulation: immunological activation and immunological suppression. This review highlights studies focusing on the immunomodulatory effects of TCMs, describing their stimulatory effect on immune cells, immune organs, cytokine production, tumorigenesis, as well as their inhibitory function on inflammation, allergy, autoimmune disease, and graft rejection. Components of both innate and adaptive immunity may be modulated by specific TCMs. TCMs may also have antitumor effects and may play a role in regulating apoptosis. Immunomodulatory effects of TCMs may lead to new medications to treat allergic and autoimmune diseases. More high quality studies are needed to achieve scientific validity to these potential treatments. Evidence presented in this review reveals the role of TCMs in immune regulation and proposes a promising future for them in immunomodulatory therapies.

Keywords

Traditional Chinese medicine (TCM) Immunomodulatory activities Immunological promotion Immunological suppression 

Notes

Acknowledgments

This study was supported by the National Basic Research Program of China (973 Program-2010CB945300), the National Natural Science Foundation of China (30972738, 31021061), and the Hundred Talents Program of the Chinese Academy of Sciences.

References

  1. 1.
    Levander OA, Whanger PD (1996) Deliberations and evaluations of the approaches, endpoints and paradigms for selenium and iodine dietary recommendations. J Nutr 126:2427S–2434SPubMedGoogle Scholar
  2. 2.
    Shils ME, Rude RK (1996) Deliberations and evaluations of the approaches, endpoints and paradigms for magnesium dietary recommendations. J Nutr 126:2398S–2403SPubMedGoogle Scholar
  3. 3.
    Frankel EN, Kanner J, German JB, Parks E, Kinsella JE (1993) Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341:454–457PubMedGoogle Scholar
  4. 4.
    Ramarathnam N, Osawa T, Ochi H, Kawakishi S (1995) The contribution of plant food antioxidants to human health. Trends Food Sci Technol 6:75–82Google Scholar
  5. 5.
    Borchers AT, Hackman RM, Keen CL, Stern JS, Gershwin ME (1997) Complementary medicine: a review of immunomodulatory effects of Chinese herbal medicines. Am J Clin Nutr 66:1303–1312PubMedGoogle Scholar
  6. 6.
    Huang CF, Lin SS, Liao PH, Young SC, Yang CC (2008) The immunopharmaceutical effects and mechanisms of herb medicine. Cell Mol Immunol 5:23–31PubMedGoogle Scholar
  7. 7.
    Jiang MH, Zhu L, Jiang JG (2010) Immunoregulatory actions of polysaccharides from Chinese herbal medicine. Expert Opin Ther Targets 14:1367–1402PubMedGoogle Scholar
  8. 8.
    Borchers AT, Sakai S, Henderson GL, Harkey MR, Keen CL, Stern JS, Terasawa K, Gershwin ME (2000) Shosaiko-to and other Kampo (Japanese herbal) medicines: a review of their immunomodulatory activities. J Ethnopharmacol 73:1–13PubMedGoogle Scholar
  9. 9.
    Chapel H, Geha R, Rosen F (2003) Primary immunodeficiency diseases: an update. Clin Exp Immunol 132:9–15PubMedGoogle Scholar
  10. 10.
    De Cock KM (2001) Epidemiology and the emergence of human immunodeficiency virus and acquired immune deficiency syndrome. Philos Trans R Soc Lond B Biol Sci 356:795–798PubMedGoogle Scholar
  11. 11.
    Kay AB (2001) Allergy and allergic diseases. First of two parts. N Engl J Med 344:30–37PubMedGoogle Scholar
  12. 12.
    Kay AB (2001) Allergy and allergic diseases. Second of two parts. N Engl J Med 344:109–113PubMedGoogle Scholar
  13. 13.
    Goodnow CC (1996) Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc Natl Acad Sci U S A 93:2264–2271PubMedGoogle Scholar
  14. 14.
    Steinman L (1996) Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85:299–302PubMedGoogle Scholar
  15. 15.
    Arakelov A, Lakkis FG (2000) The alloimmune response and effector mechanisms of allograft rejection. Semin Nephrol 20:95–102PubMedGoogle Scholar
  16. 16.
    Ezekowitz RAB, Hoffmann J (1998) Innate immunity the blossoming of innate immunity—overview. Curr Opin Immunol 10:9–11Google Scholar
  17. 17.
    Janeway CA, Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20:197–216PubMedGoogle Scholar
  18. 18.
    Bhattacharjee S, Gupta G, Bhattacharya P, Mukherjee A, Mujumdar SB, Pal A, Majumdar S (2009) Quassin alters the immunological patterns of murine macrophages through generation of nitric oxide to exert antileishmanial activity. J Antimicrob Chemother 63:317–324PubMedGoogle Scholar
  19. 19.
    Chen X, Yang L, Howard OM, Oppenheim JJ (2006) Dendritic cells as a pharmacological target of traditional Chinese medicine. Cell Mol Immunol 3:401–410PubMedGoogle Scholar
  20. 20.
    Miyazaki T, Nishijima M (1981) Studies on fungal polysaccharides. XXVII. Structural examination of a water-soluble, antitumor polysaccharide of Ganoderma lucidum. Chem Pharm Bull (Tokyo) 29:3611–3616Google Scholar
  21. 21.
    Lin YL, Liang YC, Lee SS, Chiang BL (2005) Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and p38 mitogen-activated protein kinase pathways. J Leukoc Biol 78:533–543PubMedGoogle Scholar
  22. 22.
    Tripp CS, Wolf SF, Unanue ER (1993) Interleukin-12 and tumor-necrosis-factor-alpha are costimulators of interferon-gamma production by natural-killer-cells in severe combined immunodeficiency mice with listeriosis, and interleukin-10 is a physiological antagonist. Proc Natl Acad Sci U S A 90:3725–3729PubMedGoogle Scholar
  23. 23.
    Biron CA, Nguyen KB, Pien GC, Cousens LP, Salazar-Mather TP (1999) Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol 17:189–220PubMedGoogle Scholar
  24. 24.
    Dai XD, Qin YH, Zhou CH et al (2007) Effects of Fructus psoraleae and Brucea javanica on the level of IL-2 and NK cell in rats infected with Pneumocystis carinii. Chin J Parasitol Parasit Dis 25:436–438Google Scholar
  25. 25.
    Gao Y-Q, Yao Y, Li M (2010) Effect of bushen recipe on the immune effector molecules of natural killer cells in patients with chronic hepatitis B. Zhongguo Zhong Xi Yi Jie He Za Zhi 30:710–713PubMedGoogle Scholar
  26. 26.
    Fearon DT, Locksley RM (1996) Elements of immunity—the instructive role of innate immunity in the acquired immune response. Science 272:50–54PubMedGoogle Scholar
  27. 27.
    Tseng SY, Dustin ML (2002) T-cell activation: a multidimensional signaling network. Curr Opin Cell Biol 14:575–580PubMedGoogle Scholar
  28. 28.
    Dustin ML (2003) Coordination of T cell activation and migration through formation of the immunological synapse. Immune Mech Dis 987:51–59Google Scholar
  29. 29.
    Mosmann TR, Li L, Hengartner H, Kagi D, Fu W, Sad S (1997) Differentiation and functions of T cell subsets. Mol Basis Cell Def Mech 204:148–158Google Scholar
  30. 30.
    Ikemoto K, Utsunomiya T, Ball MA, Kobayashi M, Pollard RB, Suzuki F (1994) Protective effect of shigyaku-to, a traditional Chinese herbal medicine, on the infection of herpes simplex virus type 1 (HSV-1) in mice. Experientia 50:456–460PubMedGoogle Scholar
  31. 31.
    Attele AS, Wu JA, Yuan CS (1999) Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 58:1685–1693PubMedGoogle Scholar
  32. 32.
    Lee JH, Han YM (2006) Ginsenoside Rg1 helps mice resist to disseminated candidiasis by Th1 type differentiation of CD4+ T cell. Int Immunopharmacol 6:1424–1430PubMedGoogle Scholar
  33. 33.
    Lee EJ, Ko EJ, Lee JW, Rho SW, Ko SG, Shin MK, Min BI, Hong MC, Kim SY, Bae HS (2004) Ginsenoside rg1 enhances CD4(+) T-cell activities and modulates Th1/Th2 differentiation. Int Immunopharmacol 4:235–244PubMedGoogle Scholar
  34. 34.
    Liu YJ, Zhang J, Lane PJ, Chan EY, MacLennan IC (1991) Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur J Immunol 21:2951–2962PubMedGoogle Scholar
  35. 35.
    Takemoto N, Kiyohara H, Maruyama H, Komatsu Y, Yamada H, Kawamura H (1994) A novel type of B-cell mitogen isolated from Juzen-taiho-to (TJ-48), a Japanese traditional medicine. Int J Immunopharmacol 16:919–929PubMedGoogle Scholar
  36. 36.
    Kiyohara H, Nagai T, Munakata K, Nonaka K, Hanawa T, Kim SJ, Yamada H (2006) Stimulating effect of Japanese herbal (Kampo) medicine, Hochuekkito on upper respiratory mucosal immune system. Evid Based Complement Alternat Med 3:459–467PubMedGoogle Scholar
  37. 37.
    Wu HZ, Yang F, Cui SY, Qin YF, Liu JW, Zhang YX (2007) Hematopoietic effect of fractions from the enzyme-digested colla corii asini on mice with 5-fluorouracil induced anemia. Am J Chin Med 35:853–866PubMedGoogle Scholar
  38. 38.
    Miyanomae T, Frindel E (1988) Radioprotection of hemopoiesis conferred by Acanthopanax senticosus Harms (Shigoka) administered before or after irradiation. Exp Hematol 16:801–806PubMedGoogle Scholar
  39. 39.
    Yamada H, Kiyohara H, Cyong JC, Takemoto N, Komatsu Y, Kawamura H, Aburada M, Hosoya E (1990) Fractionation and characterization of mitogenic and anti-complementary active fractions from kampo (Japanese Herbal) medicine “juzen-taiho-to”. Planta Med 56:386–391PubMedGoogle Scholar
  40. 40.
    Ohnishi Y, Yasumizu R, Fan HX, Liu J, Takao-Liu F, Komatsu Y, Hosoya E, Good RA, Ikehara S (1990) Effects of juzen-taiho-toh (TJ-48), a traditional Oriental medicine, on hematopoietic recovery from radiation injury in mice. Exp Hematol 18:18–22PubMedGoogle Scholar
  41. 41.
    Aburada M, Takeda S, Ito E, Nakamura M, Hosoya E (1983) Protective effects of juzentaihoto, dried decoctum of 10 Chinese herbs mixture, upon the adverse effects of mitomycin C in mice. J Pharmacobiodyn 6:1000–1004PubMedGoogle Scholar
  42. 42.
    Hisha H, Yamada H, Sakurai MH, Kiyohara H, Li Y, Yu C, Takemoto N, Kawamura H, Yamaura K, Shinohara S, Komatsu Y, Aburada M, Ikehara S (1997) Isolation and identification of hematopoietic stem cell-stimulating substances from Kampo (Japanese herbal) medicine, Juzen-taiho-to. Blood 90:1022–1030PubMedGoogle Scholar
  43. 43.
    Hisha H, Kohdera U, Hirayama M, Yamada H, Iguchi-Uehira T, Fan TX, Cui YZ, Yang GX, Li YA, Sugiura K, Inaba M, Kobayashi Y, Ikehara S (2002) Treatment of Shwachman syndrome by Japanese herbal medicine (Juzen-Taiho-To): stimulatory effects of its fatty acids on hemopoiesis in patients. Stem Cells 20:311–319PubMedGoogle Scholar
  44. 44.
    Hinze-Selch D, Wetter TC, Zhang Y, Lu HC, Albert ED, Mullington J, Wekerle H, Holsboer F, Pollmacher T (1998) In vivo and in vitro immune variables in patients with narcolepsy and HLA-DR2 matched controls. Neurology 50:1149–1152PubMedGoogle Scholar
  45. 45.
    Jiang J, Wu C, Gao H, Song J, Li H (2010) Effects of Astragalus polysaccharides on immunologic function of erythrocyte in chickens infected with infectious bursa disease virus. Vaccine 28:5614–5616PubMedGoogle Scholar
  46. 46.
    Oppenheim JJ (2001) Cytokines: past, present, and future. Int J Hematol 74:3–8PubMedGoogle Scholar
  47. 47.
    Burns JJ, Zhao LJ, Taylor EW, Spelman K (2010) The influence of traditional herbal formulas on cytokine activity. Toxicology 278:140–159PubMedGoogle Scholar
  48. 48.
    Calixto JB, Campos MM, Otuki MF, Santos AR (2004) Anti-inflammatory compounds of plant origin. Part II. Modulation of pro-inflammatory cytokines, chemokines and adhesion molecules. Planta Med 70:93–103PubMedGoogle Scholar
  49. 49.
    Spelman K, Burns J, Nichols D, Winters N, Ottersberg S, Tenborg M (2006) Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern Med Rev 11:128–150PubMedGoogle Scholar
  50. 50.
    Huang XX, Yamashiki M, Nakatani K, Nobori T, Mase A (2001) Semi-quantitative analysis of cytokine mRNA expression induced by the herbal medicine Sho-saiko-to (TJ-9) using a Gel Doc system. J Clin Lab Anal 15:199–209PubMedGoogle Scholar
  51. 51.
    Matsumoto T, Sakurai MH, Kiyohara H, Yamada H (2000) Orally administered decoction of Kampo (Japanese herbal) medicine, “Juzen-Taiho-To” modulates cytokine secretion and induces NKT cells in mouse liver. Immunopharmacology 46:149–161PubMedGoogle Scholar
  52. 52.
    Okamura S, Shimoda K, Li XY, Omori F, Niho Y (1991) A traditional Chinese herbal medicine, Ren-Shen-Yang-Rong-Tang (Japanese name: Ninjin-Yoei-to) augments the production of granulocyte–macrophage colony-stimulating factor from human peripheral blood mononuclear cells in vitro. Int J Immunopharmacol 13:595–598PubMedGoogle Scholar
  53. 53.
    Nakada T, Watanabe K, Jin GB, Triizuka K, Hanawa T (2002) Effect of Ninjin-Youei-To on Th1/Th2 type cytokine production in different mouse strains. Am J Chin Med 30:215–223PubMedGoogle Scholar
  54. 54.
    Li YM, Ohno Y, Minatoguchi S, Fukuda K, Ikoma T, Ohno T, Akao S, Takemura G, Gotou K, Fujiwara H (2003) Extracts from the roots of Lindera strychifolia induces apoptosis in lung cancer cells and prolongs survival of tumor-bearing mice. Am J Chin Med 31:857–869PubMedGoogle Scholar
  55. 55.
    Chan JYW, Cheung JYN, Luk SCW, Wu YJ, Pang SF, Fung KP (2004) Anti-cancer and pro-apoptotic effects of an herbal medicine and Saccharomyces cerevisiae product (CKBM) on human hepatocellular carcinoma HepG2 cells in vitro and in vivo. Immunopharmacol Immunotoxicol 26:597–609PubMedGoogle Scholar
  56. 56.
    Campbell MJ, Hamilton B, Shoemaker M, Tagliaferri M, Cohen I, Tripathy D (2002) Antiproliferative activity of Chinese medicinal herbs on breast cancer cells in vitro. Anticancer Res 22:3843–3852PubMedGoogle Scholar
  57. 57.
    Huang ST, Yang RC, Lee PN, Yang SH, Liao SK, Chen TY, Pang JHS (2006) Anti-tumor and anti-angiogenic effects of Phyllanthus urinaria in mice bearing Lewis lung carcinoma. Int Immunopharmacol 6:870–879PubMedGoogle Scholar
  58. 58.
    Lee EO, Lee HJ, Hwang HS, Ahn KS, Chae C, Kang KS, Lu JX, Kim SH (2006) Potent inhibition of Lewis lung cancer growth by heyneanol A from the roots of Vitis amurensis through apoptotic and anti-angiogenic activities. Carcinogenesis 27:2059–2069PubMedGoogle Scholar
  59. 59.
    Kato M, Liu W, Yi H, Asai N, Hayakawa A, Kozaki K, Takahashi M, Nakashima I (1998) The herbal medicine Sho-saiko-to inhibits growth and metastasis of malignant melanoma primarily developed in ret-transgenic mice. J Investig Dermatol 111:640–644PubMedGoogle Scholar
  60. 60.
    Kamiyama H, Takano S, Ishikawa E, Tsuboi K, Matsumura A (2005) Anti-angiogenic and immunomodulatory effect of the herbal medicine “Juzen-taiho-to” on malignant glioma. Biol Pharm Bull 28:2111–2116PubMedGoogle Scholar
  61. 61.
    Kumagai T, Muller CI, Desmond JC, Imai Y, Heber D, Koeffler HP (2007) Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Leuk Res 31:523–530PubMedGoogle Scholar
  62. 62.
    Lin L-W, Sun Y, He Y-M, Gao S-D, Xue E-S, Lin X-D, Yu L-Y, Lin X-F, Yang Y-H (2004) Percutaneous intratumoral injection of traditional Chinese herbal compound medicine Star-99 in treatment of hepatocellular carcinoma of mice. Hepato-Biliary-Pancreat Dis Int 3:49–54Google Scholar
  63. 63.
    Sun GP, Wang H, Xu SP, Shen YX, Wu Q, Chen ZD, Wei W (2008) Anti-tumor effects of paeonol in a HepA-hepatoma bearing mouse model via induction of tumor cell apoptosis and stimulation of IL-2 and TNF-alpha production. Eur J Pharmacol 584:246–252PubMedGoogle Scholar
  64. 64.
    Yang J-X, Wang X-M (2007) Progress in studies on anti-hepatoma effect of traditional Chinese medicine by adjusting immune function. Zhongguo Zhong Yao Za Zhi 32:281–284PubMedGoogle Scholar
  65. 65.
    Sowmyalakshmi S, Nur-e-Alam M, Akbarsha MA, Thirugnanam S, Rohr J, Chendil D (2005) Investigation on Semecarpus Lehyam—a Siddha medicine for breast cancer. Planta 220:910–918PubMedGoogle Scholar
  66. 66.
    Zhou ZW, Liu PX (2005) Progress in study of chemical constituents and anti-tumor activities of Cnidium monnieri. Zhongguo Zhong Yao Za Zhi 30:1309–1313PubMedGoogle Scholar
  67. 67.
    Ji DB, Ye J, Jiang YM, Qian BW (2009) Anti-tumor effect of Liqi, a traditional Chinese medicine prescription, in tumor bearing mice. BMC Complement Alternat Med 9:20Google Scholar
  68. 68.
    Gao Y, Huang H, Xu H, Diao Y, Dong Z (2002) Studies on the chemical constituents of Citrus medica var. sarcodactylis. Zhong Yao Cai 25:639–640PubMedGoogle Scholar
  69. 69.
    Parkin DM (2001) Global cancer statistics in the year 2000. Lancet Oncol 2:533–543PubMedGoogle Scholar
  70. 70.
    Mimura K, Baba S (1981) Determination of paeonol metabolites in man by the use of stable isotopes. Chem Pharm Bull (Tokyo) 29:2043–2050Google Scholar
  71. 71.
    Haynes BF, Markert ML, Sempowski GD, Patel DD, Hale LP (2000) The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu Rev Immunol 18:529–560PubMedGoogle Scholar
  72. 72.
    Hardy RR, Hayakawa K (2001) B cell development pathways. Annu Rev Immunol 19:595–621PubMedGoogle Scholar
  73. 73.
    Fu YX, Chaplin DD (1999) Development and maturation of secondary lymphoid tissues. Annu Rev Immunol 17:399–433PubMedGoogle Scholar
  74. 74.
    Zhang RP, Zhang XP, Ruan YF, Ye SY, Zhao HC, Cheng QH, Wu DL (2009) Protective effect of Radix Astragali injection on immune organs of rats with obstructive jaundice and its mechanism. World J Gastroenterol 15:2862–2869PubMedGoogle Scholar
  75. 75.
    He J, Li Y, Wei S, Guo M, Fu W (1992) Effects of mixture of Astragalus membranaceus, Fructus Ligustri lucidi and Eclipta prostrata on immune function in mice. Hua Xi Yi Ke Da Xue Xue Bao 23:408–411PubMedGoogle Scholar
  76. 76.
    Wu YB, Zhang YH, Wu JA, Lowell T, Gu MJ, Yuan CS (1998) Effects of Erkang, a modified formulation of Chinese folk medicine Shi-Quan-Da-Bu-Tang, on mice. J Ethnopharmacol 61:153–159PubMedGoogle Scholar
  77. 77.
    Ley K, Laudanna C, Cybulsky MI, Nourshargh S (2007) Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol 7:678–689PubMedGoogle Scholar
  78. 78.
    Stafford JL, Neumann NF, Belosevic M (2002) Macrophage-mediated innate host defense against protozoan parasites. Crit Rev Microbiol 28:187–248PubMedGoogle Scholar
  79. 79.
    Lin WW, Karin M (2007) A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest 117:1175–1183PubMedGoogle Scholar
  80. 80.
    Wynn TA (2008) Cellular and molecular mechanisms of fibrosis. J Pathol 214:199–210PubMedGoogle Scholar
  81. 81.
    Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454:436–444PubMedGoogle Scholar
  82. 82.
    Chi YS, Lim H, Park H, Kim HP (2003) Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Biochem Pharmacol 66:1271–1278PubMedGoogle Scholar
  83. 83.
    Barak V, Kalickman I, Halperin T, Birkenfeld S, Ginsburg I (2004) PADMA-28, a Tibetan herbal preparation is an inhibitor of inflammatory cytokine production. Eur Cytokine Netw 15:203–209PubMedGoogle Scholar
  84. 84.
    Yokozawa T, Rhyu DY, Cho EJ (2003) Protection by the Chinese prescription Wen-Pi-Tang against renal tubular LLC-PK1 cell damage induced by 3-morpholinosydnonimine. J Pharm Pharmacol 55:1405–1412PubMedGoogle Scholar
  85. 85.
    Yokozawa T, Satoh A, Nakagawa T, Yamabe N (2006) Attenuating effects of Wen-Pi-Tang treatment in rats with diabetic nephropathy. Am J Chin Med 34:307–321PubMedGoogle Scholar
  86. 86.
    Jung HW, Yoon CH, Kim YH, Boo YC, Park KM, Park YK (2007) Wen-Pi-Tang-Hab-Wu-Ling-San extract inhibits the release of inflammatory mediators from LPS-stimulated mouse macrophages. J Ethnopharmacol 114:439–445PubMedGoogle Scholar
  87. 87.
    Li BQ, Fu T, Gong WH, Dunlop N, Kung HF, Yan YD, Kang J, Wang JM (2000) The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Immunopharmacology 49:295–306PubMedGoogle Scholar
  88. 88.
    Charo IF, Ransohoff RM (2006) The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 354:610–621PubMedGoogle Scholar
  89. 89.
    Maddox L, Schwartz DA (2002) The pathophysiology of asthma. Annu Rev Med 53:477–498PubMedGoogle Scholar
  90. 90.
    Papageorgiou PS (2002) Clinical aspects of food allergy. Biochem Soc Trans 30:901–906PubMedGoogle Scholar
  91. 91.
    Li XM, Zhang MF, Huang CK, Srivastava K, Teper AA, Zhang LB, Schofield BH, Sampson HA (2001) Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model. J Allergy Clin Immunol 108:639–646PubMedGoogle Scholar
  92. 92.
    Srivastava KD, Kattan JD, Zou ZM, Li JH, Zhang LB, Wallenstein S, Goldfarb J, Sampson HA, Li XM (2005) The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy. J Allergy Clin Immunol 115:171–178PubMedGoogle Scholar
  93. 93.
    Chang TT, Huang CC, Hsu CH (2006) Inhibition of mite-induced immunoglobulin E synthesis, airway inflammation, and hyperreactivity by herbal medicine STA-1. Immunopharmacol Immunotoxicol 28:683–695PubMedGoogle Scholar
  94. 94.
    Busse PJ, Schofield B, Birmingham N, Yang N, Wen MC, Zhang TF, Srivastava K, Li XM (2010) The traditional Chinese herbal formula ASHMI inhibits allergic lung inflammation in antigen-sensitized and antigen-challenged aged mice. Ann Allergy Asthma Immunol 104:236–246PubMedGoogle Scholar
  95. 95.
    Oldstone MB (1998) Molecular mimicry and immune-mediated diseases. FASEB J 12:1255–1265PubMedGoogle Scholar
  96. 96.
    Lin JP, Cash JM, Doyle SZ, Peden S, Kanik K, Amos CI, Bale SJ, Wilder RL (1998) Familial clustering of rheumatoid arthritis with other autoimmune diseases. Hum Genet 103:475–482PubMedGoogle Scholar
  97. 97.
    Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725PubMedGoogle Scholar
  98. 98.
    McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, McFarland HF, Paty DW, Polman CH, Reingold SC, Sandberg-Wollheim M, Sibley W, Thompson AJ, van den Noort S, Weinshenker BY, Wolinsky JS (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the Diagnosis of Multiple Sclerosis. Ann Neurol 50:121–127PubMedGoogle Scholar
  99. 99.
    Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ (1994) Classification of chronic hepatitis—diagnosis, grading and staging. Hepatology 19:1513–1520PubMedGoogle Scholar
  100. 100.
    Wang Z, Qiu J, Guo TB, Liu A, Wang Y, Li Y, Zhang JZ (2007) Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis. J Immunol 179:5958–5965PubMedGoogle Scholar
  101. 101.
    Seo UK, Lee YJ, Kim JK, Cha BY, Kim DW, Nam KS, Kim CH (2005) Large-scale and effective screening of Korean medicinal plants for inhibitory activity on matrix metalloproteinase-9. J Ethnopharmacol 97:101–106PubMedGoogle Scholar
  102. 102.
    Kuo YC, Lin YL, Huang CP, Shu JW, Tsai WJ (2002) A tumor cell growth inhibitor from Saposhnikovae divaricata. Cancer Invest 20:955–964PubMedGoogle Scholar
  103. 103.
    Jung CH, Jun CY, Lee S, Park CH, Cho K, Ko SG (2006) Rhus verniciflua Stokes extract: radical scavenging activities and protective effects on H2O2-induced cytotoxicity in macrophage RAW 264.7 cell lines. Biol Pharm Bull 29:1603–1607PubMedGoogle Scholar
  104. 104.
    Lee JD, Huh JE, Baek YH, Cho KC, Choi DY, Park DS (2009) The efficacy and mechanism action of RvCSd, a new herbal agent, on immune suppression and cartilage protection in a mouse model of rheumatoid arthritis. J Pharmacol Sci 109:211–221PubMedGoogle Scholar
  105. 105.
    Zhang GW, Liu HY, Xia QM, Li JQ, Lu H, Zhang QH, Yao ZF (2004) Anti-rejection effect of ethanol extract of Poria cocos Wolf in rats after cardiac allograft implantation. Chin Med J 117:932–935PubMedGoogle Scholar
  106. 106.
    Ji SM, Wang QW, Chen JS, Sha GZ, Liu ZH, Li LS (2006) Clinical trial of Tripterygium wilfordii Hook F. in human kidney transplantation in China. Transplant Proc 38:1274–1279PubMedGoogle Scholar
  107. 107.
    Xu WP, Lin ZM, Yang CX, Zhang YK, Wang GM, Xu XH, Lv QZ, Ren YS, Dong Y (2009) Immunosuppressive effects of demethylzeylasteral in a rat kidney transplantation model. Int Immunopharmacol 9:996–1001PubMedGoogle Scholar
  108. 108.
    Chen BJ (2001) Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F. Leuk Lymphoma 42:253–265PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Hong-Di Ma
    • 1
    • 2
  • Yan-Ru Deng
    • 1
    • 2
  • Zhigang Tian
    • 2
  • Zhe-Xiong Lian
    • 1
    • 2
    Email author
  1. 1.Liver Immunology LaboratoryUniversity of Science and Technology of ChinaHefeiChina
  2. 2.Institute of Immunology and School of Life SciencesUniversity of Science and Technology of ChinaHefeiChina

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