Clinical Reviews in Allergy & Immunology

, Volume 42, Issue 1, pp 45–57

Umbilical Cord Blood Immunology—Relevance to Stem Cell Transplantation

  • Syh-Jae Lin
  • Dah-Chin Yan
  • Yen-Chang Lee
  • Hsiu-Shan Hsiao
  • Pei-Tzu Lee
  • Yu-Wen Liang
  • Ming-Ling Kuo
Article

DOI: 10.1007/s12016-011-8289-4

Cite this article as:
Lin, SJ., Yan, DC., Lee, YC. et al. Clinic Rev Allerg Immunol (2012) 42: 45. doi:10.1007/s12016-011-8289-4
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Abstract

Because of its easier accessibility and less severe graft-versus-host disease, umbilical cord blood (UCB) has been increasingly used as an alternative to bone marrow for hematopoietic stem cell transplantation. Naiveté of UCB lymphocytes, however, results in delayed immune reconstitution and infection-related mortality in transplant recipients. This review updates the phenotypic and functional deficiencies of various immune cell populations in UCB compared with their adult counterparts and discusses clinical implications and possible therapeutic strategies to improve the outcome of stem cell transplantation.

Keywords

Umbilical cord blood Dendritic cells T cells Regulatory T cells Natural killer cells Stem cell transplantation 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Syh-Jae Lin
    • 1
  • Dah-Chin Yan
    • 1
  • Yen-Chang Lee
    • 2
  • Hsiu-Shan Hsiao
    • 1
  • Pei-Tzu Lee
    • 1
  • Yu-Wen Liang
    • 3
  • Ming-Ling Kuo
    • 3
  1. 1.Division of Asthma, Allergy, and Rheumatology Department of Pediatrics, Chang Gung Children’s Hospital, College of MedicineChang Gung UniversityTaoyuanRepublic of China
  2. 2.Department of Obstetrics/GynecologyChang Gung Memorial HospitalTaoyuanRepublic of China
  3. 3.Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of MedicineChang Gung UniversityTaoyuanRepublic of China

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