What is Intrinsic Atopic Dermatitis?



Many authors favor a distinction between the extrinsic and intrinsic forms of atopic dermatitis. In this review, the controversy is discussed and several definitions are presented. After reviewing many papers on this topic, it is our opinion that it is useful to separate the intrinsic and extrinsic forms of atopic dermatitis or atopic eczema and atopiform dermatitis because the pathophysiology appears to be different between them. However, these terms require concrete definition and clarification of the distinction between these two concepts. This debate is a new step in the history of atopic dermatitis. It is possible that a single patient could suffer from one form and then from another but genetic differences suggest that two types could really exist.


Atopic dermatitis Intrinsic Filaggrin Beta-adrenergic Stress Skin barrier 


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.University of BrestBrest CedexFrance
  2. 2.Department of Dermatology and Laboratory of Skin NeurobiologyUniversity HospitalBrestFrance

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