Clinical Reviews in Allergy & Immunology

, Volume 42, Issue 3, pp 322–330

The Clinical Significance of 25OH-Vitamin D Status in Celiac Disease

  • Aaron Lerner
  • Yinon Shapira
  • Nancy Agmon-Levin
  • Avi Pacht
  • Dana Ben-Ami Shor
  • Hoyos Marcus López
  • Maria Sanchez-Castanon
  • Yehuda Shoenfeld


Reduced bone mineral density is frequently found especially in adult celiac disease (CD) and dietary guidelines favor vitamin D supplementation in adults and children with CD. Vitamin D serum levels were investigated in CD populations in order to challenge its routine supplementation. Israeli (61), Spanish (59), CD children (groups 1 and 5, respectively) were compared to children with nonspecific abdominal pain (56), their parents (84) and Spanish adult CD patients (22) (group 2, 3, 4, respectively). 25(OH)-vitamin D was checked by LIAISON chemiluminescent immunoassays. Groups 5 and 1 had the highest levels compared to groups 4 and 3 with the lowest levels. The levels in groups 1 and 2 were comparable. Concerning 25(OH)-vitamin D sera levels, only the difference between group 5 and 4 was statistically significant (30.3 ± 12.3 and 20.2 ± 10.5 ng/ml, respectively p = 0.003). When vitamin D was splitted above and below 20 ng/ml level, 54.5% of Spanish adult CD had vitamin D deficiency compared to 16.9% of the local CD children (p = 0.001). 29.6% of group 2 had deficient levels compared to their parents with 50% (p = 0.019). In conclusion, Vitamin D sera levels negatively correlate with age. Thus, mainly adult CD population should be assessed for vitamin D levels and supplemented accordingly.


Celiac disease Vitamin D Children Adults Autoimmunity Israel Spain 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Aaron Lerner
    • 1
    • 4
  • Yinon Shapira
    • 2
  • Nancy Agmon-Levin
    • 2
  • Avi Pacht
    • 1
  • Dana Ben-Ami Shor
    • 2
  • Hoyos Marcus López
    • 3
  • Maria Sanchez-Castanon
    • 3
  • Yehuda Shoenfeld
    • 2
  1. 1.Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, B. Rappaport School of MedicineTechnion-Israel Institute of TechnologyHaifaIsrael
  2. 2.The Zabludowicz Center for Autoimmune Diseases and Department of Medicine B, Sheba Medical Center, Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael
  3. 3.Servicio Inmunología Hospital Universitario Marqués de ValdecillaSantanderSpain
  4. 4.Pediatric Gastroenterology and Nutrition Unit, Carmel Medical CenterHaifaIsrael

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