Clinical Reviews in Allergy & Immunology

, Volume 42, Issue 3, pp 309–321

Cutting Edge Issues in Autoimmune Hepatitis

Article

DOI: 10.1007/s12016-010-8236-9

Cite this article as:
Vergani, D. & Mieli-Vergani, G. Clinic Rev Allerg Immunol (2012) 42: 309. doi:10.1007/s12016-010-8236-9

Abstract

Autoimmune hepatitis is an inflammatory liver disease affecting mainly females and characterised histologically by interface hepatitis, biochemically by elevated transaminase levels and serologically by circulating autoantibodies and increased levels of immunoglobulin G. Autoimmune hepatitis responds to immunosuppressive treatment, which should be instituted as soon as diagnosis is made. Seropositivity for smooth muscle and/or antinuclear antibody defines type 1 autoimmune hepatitis, while positivity for liver kidney microsomal type 1 antibody defines type 2 autoimmune hepatitis. The aetiology of autoimmune hepatitis is unknown, though both genetic and environmental factors are involved in its expression. The major mechanism of liver damage involves immune reactions against host liver antigens that are not adequately controlled by defective regulatory T cells. Current research aiming at potentiating regulatory T cell function in vitro to reconstitute tolerance in vivo has given promising results.

Keywords

Autoimmune hepatitis Liver Autoantibody Humoral immunity Cellular immunity Immune regulation 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Institute of Liver StudiesKing’s College London School of Medicine at King’s College HospitalLondonUK

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