Clinical Reviews in Allergy & Immunology

, Volume 41, Issue 1, pp 4–19 | Cite as

Identification of European Allergy Patterns to the Allergen Families PR-10, LTP, and Profilin from Rosaceae Fruits

  • Maj-Britt Schmidt Andersen
  • Sharon Hall
  • Lars Ove DragstedEmail author


High fruit intakes are associated with significant health benefits but fruit allergy sufferers may be discouraged from eating fruit due to the symptoms they experience. Knowledge about allergens involved in fruit allergy and the frequent cross-reactions to other allergens is essential to (a) design the best strategy for fruit allergy testing (b) prescribe optimal avoidance diets, and (c) design technological solutions for development of hypoallergenic fruits. The objective of this review was to investigate whether some characteristic disease entities could be identified in Europe for allergy to Rosaceae fruits. Five allergy patterns were found involving the allergen families PR-10, LTP, and profilin. In the Western Mediterranean area allergies to Rosaceae fruits are caused by monosensitization to LTP, monosensitization to profilin, or co-sensitization to both these allergens. On the contrary, monosensitization to PR-10 and, to a lesser degree, co-sensitization to profilin and PR-10 is dominant in Northern and Central Europe. LTP sensitization is present both in pollinosis and non-pollinosis patients and is associated with peach allergy in particular. The disease pattern for patients sensitized to profilin is characterized by several concomitant allergies including grass and other pollens, Rosaceae and non-Rosaceae fruits. Finally, PR-10 sensitization is primarily associated to concomitant birch pollen and apple allergy.


Allergens Avoidance diets European allergy patterns Fruit allergy Rosaceae 


  1. 1.
    Vainio H, Weiderpass E (2006) Fruit and vegetables in cancer prevention. Nutrition and Cancer-An International Journal 54(1):111–142CrossRefGoogle Scholar
  2. 2.
    Hamer M, Chida Y (2007) Intake of fruit, vegetables, and antioxidants and risk of type 2 diabetes: systematic review and meta-analysis. J Hypertens 25(12):2361–2369PubMedCrossRefGoogle Scholar
  3. 3.
    He FJ, Nowson CA, MacGregor GA (2006) Fruit and vegetable consumption and stroke: meta-analysis of cohort studies. Lancet 367(9507):320–326PubMedCrossRefGoogle Scholar
  4. 4.
    Dauchet L, Amouyel P, Dallongeville J (2005) Fruit and vegetable consumption and risk of stroke—a meta-analysis of cohort studies. Neurology 65(8):1193–1197PubMedCrossRefGoogle Scholar
  5. 5.
    He FJ, Nowson CA, Lucas M, MacGregor GA (2007) Increased consumption of fruit and vegetables is related to a reduced risk of coronary heart disease: meta-analysis of cohort studies. J Hum Hypertens 21(9):717–728PubMedCrossRefGoogle Scholar
  6. 6.
    Dauchet L, Amouyel P, Hercberg S, Dallongeville J (2006) Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies. J Nutr 136(10):2588–2593PubMedGoogle Scholar
  7. 7.
    Increasing Fruit Consumption to Improve Health (2008) ISAFRUIT Forum. Scripta Horticulturae. Report No. 8, Oct 28Google Scholar
  8. 8.
    Zuidmeer L, Goldhahn K, Rona RJ, Gislason D, Madsen C, Summers C et al (2008) The prevalence of plant food allergies: a systematic review. J Allergy Clin Immunol 121(5):1210–1218PubMedCrossRefGoogle Scholar
  9. 9.
    Young E, Stoneham MD, Petruckevitch A, Barton J, Rona R (1994) A population study of food intolerance. Lancet 343(8906):1127–1130PubMedCrossRefGoogle Scholar
  10. 10.
    Alvarado MI, Pérez M (2006) Study of food allergy in the Spanish population. Allergol Immunopathol 34(5):185–193CrossRefGoogle Scholar
  11. 11.
    Fernandez-Rivas M, Bolhaar S, Gonzalez-Mancebo E, Asero R, van Leeuwen A, Bohle B et al (2006) Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods. J Allergy Clin Immunol 118(2):481–488PubMedCrossRefGoogle Scholar
  12. 12.
    Reuter A, Lidholm J, Andersson K, Ostling J, Lundberg M, Scheurer S et al (2006) A critical assessment of allergen component-based in vitro diagnosis in cherry allergy across Europe. Clin Exp Allergy 36(6):815–823PubMedCrossRefGoogle Scholar
  13. 13.
    Eriksson NE, Moller C, Bengtsson U, Wihl JA (2004) Food hypersensitivity in patients of Swedish allergy centers. Allergologie 27(6):233–243Google Scholar
  14. 14.
    Eriksson NE, Moller C, Werner S, Magnusson J, Bengtsson U, Zolubas M (2004) Self-reported food hypersensitivity in Sweden, Denmark, Estonia, Lithuania, and Russia. J Investig Allergol Clin Immunol 14(1):70–79PubMedGoogle Scholar
  15. 15.
    Woods RK, Abramson M, Bailey M, Walters EH (2001) International prevalences of reported food allergies and intolerances. Comparisons arising from the European Community Respiratory Health Survey (ECRHS) 1991–1994. Eur J Clin Nutr 55(4):298–304PubMedCrossRefGoogle Scholar
  16. 16.
    Zuberbier T, Edenharter G, Worm M, Ehlers I, Reimann S, Hantke T et al (2004) Prevalence of adverse reactions to food in Germany—a population study. Allergy 59(3):338–345PubMedCrossRefGoogle Scholar
  17. 17.
    Cuesta-Herranz J, Lazaro M, Figueredo E, Igea JM, Umpierrez A, De-Las-Heras M (2000) Allergy to plant-derived fresh foods in a birch- and ragweed-free area. Clin Exp Allergy 30(10):1411–1416PubMedCrossRefGoogle Scholar
  18. 18.
    Lázaro M, Cuesta J, Igea JM (1999) Allergy to Rosaceae: the peach. Alergol Inmunol Clin 14(4):234–240Google Scholar
  19. 19.
    Falcao H, Lunet N, Lopes C, Barros H (2004) Food hypersensitivity in Portuguese adults. Eur J Clin Nutr 58(12):1621–1625PubMedCrossRefGoogle Scholar
  20. 20.
    Primavesi L, Brenna OV, Pompei C, Pravettoni V, Farioli L, Pastorello EA (2006) Influence of cultivar and processing on cherry (Prunus avium) allergenicity. J Agric Food Chem 54(26):9930–9935PubMedCrossRefGoogle Scholar
  21. 21.
    Sicherer SH (2001) Clinical implications of cross-reactive food allergens. J Allergy Clin Immunol 108(6):881–890PubMedCrossRefGoogle Scholar
  22. 22.
    Asero R, Ballmer-Weber BK, Beyer K, Conti A, Dubakiene R, Fernandez-Rivas M et al (2007) IgE-Mediated food allergy diagnosis: current status and new perspectives. Mol Nutr Food Res 51(1):135–147PubMedCrossRefGoogle Scholar
  23. 23.
    Hofmann A, Burks AW (2008) Pollen food syndrome: update on the allergens. Curr Allergy and Asthma Rep 8(5):413–417CrossRefGoogle Scholar
  24. 24.
    Pastorello EA, D'Ambrosio FP, Pravettoni V, Farioli L, Giuffrida G, Monza M et al (2000) Evidence for a lipid transfer protein as the major allergen of apricot. J Allergy Clin Immunol 105(2):371–377PubMedCrossRefGoogle Scholar
  25. 25.
    Salcedo G, Sanchez-Monge R, Barber D, az-Perales A (2007) Plant non-specific lipid transfer proteins: an interface between plant defence and human allergy. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids 1771(6):781–791CrossRefGoogle Scholar
  26. 26.
    Nicoletti C, Temblay JN, Ivory K (2007) The immune system and allergic responses to food. In: Mills C, Wichers H, Hoffmann-Sommergruber K (eds) Managing allergens in food. Woodhead, Cambridge, pp 29–46CrossRefGoogle Scholar
  27. 27.
    Bousquet J, Anto JM, Bachert C, Bousquet PJ, Colombo P, Crameri R et al (2006) Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GA(2)LEN project. Allergy 61(6):671–680PubMedCrossRefGoogle Scholar
  28. 28.
    Breiteneder H, Radauer C (2004) A classification of plant food allergens. J Allergy Clin Immunol 113(5):821–830PubMedCrossRefGoogle Scholar
  29. 29.
    International Union of Immunological Societies. Allergen Nomenclature Sub-Committee. 9-5-2009. Ref Type: Internet Communication
  30. 30.
    Midoro-Horiuti T, Brooks EG, Goldblum RM (2001) Pathogenesis-related proteins of plants as allergens. Ann Allergy Asthma Immunol 87(4):261–271PubMedCrossRefGoogle Scholar
  31. 31.
    Puehringer HM, Zinoecker I, Marzban G, Katinger H, Laimer M (2003) MdAP, a novel protein in apple, is associated with the major allergen Mal d 1. Gene 321:173–183PubMedCrossRefGoogle Scholar
  32. 32.
    Ebner C, Birkner T, Valenta R, Rumpold H, Breitenbach M, Scheiner O et al (1991) Common epitopes of birch pollen and apples—studies by Western and Northern Blot. J Allergy Clin Immunol 88(4):588–594PubMedCrossRefGoogle Scholar
  33. 33.
    Vanekkrebitz M, Hoffmannsommergruber K, Machado MLD, Susani M, Ebner C, Kraft D et al (1995) Cloning and sequencing of Mal-D-1, the major allergen from apple (Malus domestica), and its immunological relationship to Bet-V-1, the major birch pollen allergen. Biochem Biophys Res Commun 214(2):538–551CrossRefGoogle Scholar
  34. 34.
    Gaier S, Marsh J, Oberhuber C, Rigby NM, Lovegrove A, Alessandri S et al (2008) Purification and structural stability of the peach allergens Pru p 1 and Pru p 3. Mol Nutr Food Res 52:S220–S229PubMedGoogle Scholar
  35. 35.
    Ebner C, Hirschwehr R, Bauer L, Breiteneder H, Valenta R, Ebner H et al (1995) Identification of allergens in fruits and vegetables—Ige cross-reactivities with the important birch pollen allergens Bet-V-1 and Bet-V-2 (birch profilin). J Allergy Clin Immunol 95(5):962–969PubMedCrossRefGoogle Scholar
  36. 36.
    Scheurer S, Son DY, Boehm M, Karamloo F, Franke S, Hoffmann A et al (1999) Cross-reactivity and epitope analysis of Pru a 1, the major cherry allergen. Mol Immunol 36(3):155–167PubMedCrossRefGoogle Scholar
  37. 37.
    Bohle B, Zwoelfer B, Heratizadeh A, Jahn-Schmid B, Antonia YD, Alter M et al (2006) Cooking birch pollen-related food: divergent consequences for IgE- and T cell-mediated reactivity in vitro and in vivo. J Allergy Clin Immunol 118(1):242–249PubMedCrossRefGoogle Scholar
  38. 38.
    Scheurer S, Lauer I, Foetisch K, Moncin MSM, Retzek M, Hartz C et al (2004) Strong allergenicity of Pru av 3, the lipid transfer protein from cherry, is related to high stability against thermal processing and digestion. J Allergy Clin Immunol 114(4):900–907PubMedCrossRefGoogle Scholar
  39. 39.
    Asero R, Mistrello G, Roncarolo D, Amato S (2006) SPT with heat-processed apple peel extract to detect LTP hypersensitivity. European annals of allergy and clinical immunology 38(10):351–354PubMedGoogle Scholar
  40. 40.
    Hsieh LS, Moos M, Lin Y (1995) Characterization of apple 18 and 31 kD allergens by microsequencing and evaluation of their content during storage and ripening. J Allergy Clin Immunol 96(6):960–970PubMedCrossRefGoogle Scholar
  41. 41.
    Salcedo G, Sanchez-Monge R, az-Prales A, Garcia-Casado G, Barber D (2004) Plant non-specific lipid transfer proteins as food and pollen allergens. Clin Exp Allergy 34(9):1336–1341PubMedCrossRefGoogle Scholar
  42. 42.
    Diaz-Perales A, Garcia-Casado G, Sanchez-Monge R, Garcia-Selles FJ, Barber D, Salcedo G (2002) cDNA cloning and heterologous expression of the major allergens from peach and apple belonging to the lipid-transfer protein family. Clin Exp Allergy 32(1):87–92PubMedCrossRefGoogle Scholar
  43. 43.
    Pastorello EA, Pravettoni V, Farioli L, Rivolta F, Conti A, Ispano M et al (2002) Hypersensitivity to mugwort (Artemisia vulgaris) in patients with peach allergy is due to a common lipid transfer protein allergen and is often without clinical expression. J Allergy Clin Immunol 110(2):310–317PubMedCrossRefGoogle Scholar
  44. 44.
    Lombardero M, Garcia-Selles FJ, Polo F, Jimeno L, Chamorro MJ, Garcia-Casado G et al (2004) Prevalence of sensitization to Artemisia allergens Art v 1, Art v 3 and Art v 60 kDa. Cross-reactivity among Art v 3 and other relevant lipid-transfer protein allergens. Clin Exp Allergy 34(9):1415–1421PubMedCrossRefGoogle Scholar
  45. 45.
    Diaz-Perales A, Lombardero M, Sanchez-Monge R, Garcia-Selles FJ, Pernas M, Fernandez-Rivas M et al (2000) Lipid-transfer proteins as potential plant panallergens: cross-reactivity among proteins of Artemisia pollen, Castanea nut and Rosaceae fruits, with different IgE-binding capacities. Clin Exp Allergy 30(10):1403–1410PubMedCrossRefGoogle Scholar
  46. 46.
    Pastorello EA, Farioli L, Pravettoni V, Giuffrida MG, Ortolani C, Fortunato D et al (2001) Characterization of the major allergen of plum as a lipid transfer protein. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 756(1–2):95–103CrossRefGoogle Scholar
  47. 47.
    Borges JP, Barre A, Culerrier R, Grainer C, Didier A, Rouge P (2008) Lipid transfer proteins from Rosaceae fruits share consensus epitopes responsible for their IgE-binding cross-reactivity. Biochem Biophys Res Commun 365(4):685–690PubMedCrossRefGoogle Scholar
  48. 48.
    Pastorello EA, Robino AM (2004) Clinical role of lipid transfer proteins in food allergy. Mol Nutr Food Res 48(5):356–362PubMedCrossRefGoogle Scholar
  49. 49.
    van Ree R (2002) Clinical importance of non-specific lipid transfer proteins as food allergens. Biochem Soc Trans 30:910–913PubMedCrossRefGoogle Scholar
  50. 50.
    Asero R, Mistrello G, Roncarolo D, Amato S, Falagiani P (2003) Analysis of the heat stability of lipid transfer protein from apple. J Allergy Clin Immunol 112(5):1009–1011PubMedCrossRefGoogle Scholar
  51. 51.
    Carnes J, Fernandez-Caldas E, Gallego MT, Ferrer A, Cuesta-Herranz J (2002) Pru p 3 (LTP) content in peach extracts. Allergy 57(11):1071–1075PubMedCrossRefGoogle Scholar
  52. 52.
    Fernandez-Rivas M, Cuevas M (1999) Peels of Rosaceae fruits have a higher allergenicity than pulps. Clin Exp Allergy 29(9):1239–1247PubMedCrossRefGoogle Scholar
  53. 53.
    Marzban G, Puehringer H, Dey R, Brynda S, Ma Y, Martinelli A et al (2005) Localisation and distribution of the major allergens in apple fruits. Plant Sci 169(2):387–394CrossRefGoogle Scholar
  54. 54.
    Borges JP, Jauneau A, Brule C, Culerrier R, Barre A, Didier A et al (2006) The lipid transfer proteins (LTP) essentially concentrate in the skin of Rosaceae fruits as cell surface exposed allergens. Plant Physiol Biochem 44(10):535–542PubMedCrossRefGoogle Scholar
  55. 55.
    Scheurer S, Wangorsch A, Nerkamp J, Skov PS, Ballmer-Weber B, Wuthrich B et al (2001) Cross-reactivity within the profilin panallergen family investigated by comparison of recombinant profilins from pear (Pyr c 4), cherry (Pru av 4) and celery (Api g 4) with birch pollen profilin Bet v 2. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 756(1–2):315–325CrossRefGoogle Scholar
  56. 56.
    Fedorov AA, Ball T, Mahoney NM, Valenta R, Almo SC (1997) The molecular basis for allergen cross-reactivity: crystal structure and IgE-epitope mapping of birch pollen profilin. Structure 5(1):33–45PubMedCrossRefGoogle Scholar
  57. 57.
    Radauer C, Willerroider M, Fuchs H, Hoffmann-Sommergruber K, Thalhamer J, Ferreira F et al (2006) Cross-reactive and species-specific immunoglobulin E epitopes of plant profilins: an experimental and structure-based analysis. Clin Exp Allergy 36(7):920–929PubMedCrossRefGoogle Scholar
  58. 58.
    Ma Y, Zuidmeer L, Bohle B, Bolhaarz STH, Gadermaier G, Gonzalez-Mancebo E et al (2006) Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy. Clin Exp Allergy 36(8):1087–1096PubMedCrossRefGoogle Scholar
  59. 59.
    Diaz-Perales A, Sanz ML, Garcia-Casado G, Sanchez-Monge R, Garcia-Selles FJ, Lombardero M et al (2003) Recombinant Pru p 3 and natural Pru p 3, a major peach allergen, show equivalent immunologic reactivity: a new tool for the diagnosis of fruit allergy. J Allergy Clin Immunol 111(3):628–633PubMedCrossRefGoogle Scholar
  60. 60.
    Gamboa PM, Sanz ML, Lombardero M, Barber D, Sanchez-Monje R, Goikoetxea MJ et al (2009) Component-resolved in vitro diagnosis in peach-allergic patients. J Investig Allergol Clin Immunol 19(1):13–20PubMedGoogle Scholar
  61. 61.
    Scheurer S, Metzner K, Haustein D, Vieths S (1997) Molecular cloning, expression and characterization of Pru a 1, the major cherry allergen. Mol Immunol 34(8–9):619–629PubMedCrossRefGoogle Scholar
  62. 62.
    Fernandez-Rivas M, Gonzalez-Mancebo E, Rodriguez-Perez R, Benito C, Sanchez-Monge R, Salcedo G et al (2003) Clinically relevant peach allergy is related to peach lipid transfer protein, Pru p 3, in the Spanish population. J Allergy Clin Immunol 112(4):789–795PubMedCrossRefGoogle Scholar
  63. 63.
    Rossi RE, Monasterolo G, Operti D, Corsi M (1996) Evaluation of recombinant allergens Bet v 1 and Bet v 2 (profilin) by Pharmacia CAP system in patients with pollen-related allergy to birch and apple. Allergy 51(12):940–945PubMedGoogle Scholar
  64. 64.
    Ballmer-Weber BK, Scheurer S, Fritsche P, Enrique E, Cistero-Bahima A, Haase T et al (2002) Component-resolved diagnosis with recombinant allergens in patients with cherry allergy. J Allergy Clin Immunol 110(1):167–173PubMedCrossRefGoogle Scholar
  65. 65.
    Fernandez-Rivas M, van Ree R, Cuevas M (1997) Allergy to Rosaceae fruits without related pollinosis. J Allergy Clin Immunol 100(6):728–733PubMedCrossRefGoogle Scholar
  66. 66.
    Mari A, Wallner M, Ferreira F (2003) Fagales pollen sensitization in a birch-free area: a respiratory cohort survey using Fagales pollen extracts and birch recombinant allergens (rBet v 1, rBet v 2, rBet v 4). Clin Exp Allergy 33:1419–1428PubMedCrossRefGoogle Scholar
  67. 67.
    Cuesta-Herranz J, Lazaro M, Martinez A, Figueredo E, Palacios R, de-Las-Heras M et al (1999) Pollen allergy in peach-allergic patients: sensitization and cross-reactivity to taxonomically unrelated pollens. J Allergy Clin Immunol 104(3):688–694PubMedCrossRefGoogle Scholar
  68. 68.
    Wensing M, Akkerdaas JH, van Leeuwen A, Stapel SO, Bruijnzeel-Koomen CAFM, Aalberse RC et al (2002) IgE to Bet v 1 and profilin: cross-reactivity patterns and clinical relevance. J Allergy Clin Immunol 110(3):435–442PubMedCrossRefGoogle Scholar
  69. 69.
    Bjorksten F, Halmepuro L, Hannuksela M, Lahti A (1980) Extraction and properties of apple allergens. Allergy 35(8):671–677PubMedCrossRefGoogle Scholar
  70. 70.
    Asero R, Antonicelli L, Arena A, Bommarito L, Caruso B, Crivellaro M et al (2009) EpidemAAITO: features of food allergy in Italian adults attending allergy clinics: a multi-centre study. Clin Exp Allergy 39(4):547–555PubMedCrossRefGoogle Scholar
  71. 71.
    Fernandez-Rivas M, Miles S (2004) Food allergies: clinical and psychosocial perspectives. In: Mills ENC, Shewry PR (eds) Plant food allergens. Blackwell, Oxford, pp 1–23Google Scholar
  72. 72.
    Ballmer-Weber BK (2002) Lipid transfer protein as a potential panallergen? Allergy 57(10):873–875PubMedCrossRefGoogle Scholar
  73. 73.
    Asero R, Mistrello G, Roncarolo D, Amato S (2007) Detection of some safe plant-derived foods for LTP-allergic patients. Int Arch Allergy Immunol 144:57–63PubMedCrossRefGoogle Scholar
  74. 74.
    Pastorello EA, Farioli L, Pravettoni V, Ortolani C, Ispano M, Monza M et al (1999) The major allergen of peach (Prunus persica) is a lipid transfer protein. J Allergy Clin Immunol 103(3):520–526PubMedCrossRefGoogle Scholar
  75. 75.
    Pastorello EA, Pravettoni V, Farioli L, Ispano M, Fortunato D, Monza M et al (1999) Clinical role of a lipid transfer protein that acts as a new apple-specific allergen. J Allergy Clin Immunol 104(5):1099–1106PubMedCrossRefGoogle Scholar
  76. 76.
    Pastorello EA, Ortolani C, Farioli L, Pravettoni V, Ispano M, Borga A et al (1994) Allergenic cross-reactivity among peach, apricot, plum, and cherry in patients with oral allergy syndrome—an in-vivo and in-vitro study. J Allergy Clin Immunol 94(4):699–707PubMedCrossRefGoogle Scholar
  77. 77.
    D'Amato G, Cecchi L, Bonini S, Nunes C, Nnesi-Maesano I, Behrendt H et al (2007) Allergenic pollen and pollen allergy in Europe. Allergy 62(9):976–990PubMedCrossRefGoogle Scholar
  78. 78.
    van Ree R, Fernandezrivas M, Cuevas M, Vanwijngaarden M, Aalberse RC (1995) Pollen-related allergy to peach and apple—an important role for profilin. J Allergy Clin Immunol 95(3):726–734PubMedCrossRefGoogle Scholar
  79. 79.
    Lauer I, Miguel-Moncin MS, Abel T, Foetisch K, Hartz C, Fortunato D et al (2007) Identification of a plane pollen lipid transfer protein (Pla a 3) and its immunological relation to the peach lipid-transfer protein, Pru p 3. Clin Exp Allergy 37(2):261–269PubMedCrossRefGoogle Scholar
  80. 80.
    Daschner A, Crespo JF, Pascual CY (1998) Specific IgE to recombinant vegetal panallergen (rBet v 2) and fruit allergy in pollinic patients. Allergy 53(6):614–618PubMedCrossRefGoogle Scholar
  81. 81.
    Garcia-Selles FJ, az-Perales A, Sanchez-Monge R, Alcantara M, Lombardero M, Barber D et al (2002) Patterns of reactivity to lipid transfer proteins of plant foods and Artemisia pollen: an in vivo study. Int Arch Allergy Immunol 128(2):115–122PubMedCrossRefGoogle Scholar
  82. 82.
    Díez-Gómez ML, Quirce S, Cuevas M, Sánchez-Fernández C, Baz G, Moradiellos FJ et al (1999) Fruit-pollen-latex cross-reactivity: implication of profilin (Bet v 2). Allergy 54(9):951–961PubMedCrossRefGoogle Scholar
  83. 83.
    Rodriguez-Perez R, Fernandez-Rivas M, Gonzalez-Mancebo E, Sanchez-Monge R, az-Perales A, Salcedo G (2003) Peach profilin: cloning, heterologous expression and cross-reactivity with Bet v 2. Allergy 58(7):635–640PubMedCrossRefGoogle Scholar
  84. 84.
    Gamboa PM, Cáceres O, Antepara I, Sanchez-Monge R, Ahrazem O, Salcedo G et al (2007) Two different profiles of peach allergy in the north of Spain. Allergy 62:408–414PubMedCrossRefGoogle Scholar
  85. 85.
    Gonzalez-Mancebo E, Rodriguez-Perez R, Alonso MD, Rosado A, Tejedor MA, Vila C et al (2002) Peach allergy. Clinical characteristics and allergen sensitization in 84 patients evaluated by DBPCFC. Allergy 57:27CrossRefGoogle Scholar
  86. 86.
    Zuidmeer L, Salentijn E, Rivas MF, Mancebo EG, Asero R, Matos CI et al (2006) The role of profilin and lipid transfer protein in strawberry allergy in the Mediterranean area. Clin Exp Allergy 36(5):666–675PubMedCrossRefGoogle Scholar
  87. 87.
    Rodrigues-Alves R, Lopez A, Pereira-Santos MC, Lopes-Silva S, Spínola-Santos A, Costa C et al (2009) Clinical, anamnestic and serological features of peach allergy in Portugal. Int Arch Allergy Immunol 149:65–73PubMedCrossRefGoogle Scholar
  88. 88.
    Scheurer S, Pastorello EA, Wangorsch A, Kastner M, Haustein D, Vieths S (2001) Recombinant allergens Pro av 1 and Pru av 4 and a newly identified lipid transfer protein in the in vitro diagnosis of cherry allergy. J Allergy Clin Immunol 107(4):724–731PubMedCrossRefGoogle Scholar
  89. 89.
    Pauli G, Oster JP, Deviller P, Heiss S, Bessot JC, Susani M et al (1996) Skin testing with recombinant allergens rBet v 1 and birch profilin, rBet v 2: diagnostic value for birch pollen and associated allergies. J Allergy Clin Immunol 97(5):1100–1109PubMedCrossRefGoogle Scholar
  90. 90.
    Erdmann SM, Sachs B, Schmidt A, Merk HF, Scheiner O, Moll-Slodowy S et al (2005) In vitro analysis of birch-pollen-associated food allergy by use of recombinant allergens in the basophil activation test. Int Arch Allergy Immunol 136(3):230–238PubMedCrossRefGoogle Scholar
  91. 91.
    Karamloo F, Scheurer S, Wangorsch A, May S, Haustein D, Vieths S (2001) Pyr c 1, the major allergen from pear (Pyrus communis), is a new member of the Bet v 1 allergen family. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 756(1–2):281–293CrossRefGoogle Scholar
  92. 92.
    Asero R, Monsalve R, Barber D (2008) Profilin sensitization detected in the office by skin prick test: a study of prevalence and clinical relevance of profilin as a plant food allergen. Clin Exp Allergy 38(6):1033–1037PubMedCrossRefGoogle Scholar
  93. 93.
    Rodriguez J, Crespo JF, Lopez-Rubio A, de la Cruz-Bertolo J, Ferrando-Vivas P, Vives R et al (2000) Clinical cross-reactivity among foods of the Rosaceae family. J Allergy Clin Immunol 106(1):183–189PubMedCrossRefGoogle Scholar
  94. 94.
    Ortolani C, Ispano M, Pastorello E, Bigi A, Ansaloni R (1988) The oral allergy syndrome. Annals of Allergy 61(6):47–52PubMedGoogle Scholar
  95. 95.
    Asero R, Mistrello G, Roncarolo D, Amato S, Zanoni D, Barocci F et al (2003) Detection of clinical markers of sensitization to profilin in patients allergic to plant-derived foods. J Allergy Clin Immunol 112(2):427–432PubMedCrossRefGoogle Scholar
  96. 96.
    Bircher AJ, Vanmelle G, Haller E, Curty B, Frei PC (1994) IgE to food allergens are highly prevalent in patients allergic to pollens, with and without symptoms of food allergy. Clin Exp Allergy 24(4):367–374PubMedCrossRefGoogle Scholar
  97. 97.
    Calkhoven PG, Aalbers M, Koshte VL, Pos O, Oei HD, Aalberse RC (1987) Cross-reactivity among birch pollen, vegetables and fruits as detected by IgE antibodies is due to at least three distinct cross-reactive structures. Allergy 42(5):382–390PubMedCrossRefGoogle Scholar
  98. 98.
    Eriksson NE, Formgren H, Svenonius E (1982) Food hypersensitivity in patients with pollen allergy. Allergy 37(6):437–443PubMedCrossRefGoogle Scholar
  99. 99.
    Sicherer SH (2000) Determinants of systemic manifestations of food allergy. J Allergy Clin Immunol 106(5):251–257CrossRefGoogle Scholar
  100. 100.
    Holm J, Baerentzen G, Gajhede M, Ipsen H, Larsen JN, Lowenstein H et al (2001) Molecular basis of allergic cross-reactivity between group 1 major allergens from birch and apple. Journal of Chromatography B 756(1–2):307–313CrossRefGoogle Scholar
  101. 101.
    Ferreira F, Hawranek T, Gruber P, Wopfner N, Mari A (2004) Allergic cross-reactivity: from gene to the clinic. Allergy 59(3):243–267PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Maj-Britt Schmidt Andersen
    • 1
  • Sharon Hall
    • 2
  • Lars Ove Dragsted
    • 1
    • 3
    Email author
  1. 1.Faculty of Life Sciences, Department of Human NutritionUniversity of CopenhagenCopenhagenDenmark
  2. 2.Warwick HRIUniversity of WarwickCoventryUK
  3. 3.Frederiksberg CDenmark

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