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Clinical Reviews in Allergy & Immunology

, Volume 39, Issue 1, pp 10–19 | Cite as

Epigenetics in Rheumatoid Arthritis

  • Michelle Trenkmann
  • Matthias Brock
  • Caroline Ospelt
  • Steffen Gay
Article

Abstract

Epigenetics is a steadily growing research area. In many human diseases, especially in cancers, but also in autoimmune diseases, epigenetic aberrations have been found. Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation and destruction of synovial joints. Even though the etiology is not yet fully understood, rheumatoid arthritis is generally considered to be caused by a combination of genetic predisposition, deregulated immunomodulation, and environmental influences. To gain a better understanding of this disease, researchers have become interested in studying epigenetic changes in rheumatoid arthritis. Here, we want to review the current knowledge on epigenetics in rheumatoid arthritis.

Keywords

Rheumatoid arthritis Histone Histone deacetylases 

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Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  • Michelle Trenkmann
    • 1
  • Matthias Brock
    • 1
    • 2
  • Caroline Ospelt
    • 1
  • Steffen Gay
    • 1
    • 3
  1. 1.Center of Experimental Rheumatology and Zurich Center for Integrative Human Physiology (ZIHP)University of ZurichZurichSwitzerland
  2. 2.Working Group for Pulmonary Hypertension, Department for Internal MedicineUniversity Hospital ZurichZurichSwitzerland
  3. 3.Center of Experimental RheumatologyUniversity Hospital ZurichZurichSwitzerland

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