Clinical Reviews in Allergy & Immunology

, Volume 38, Issue 2–3, pp 298–301 | Cite as

Diagnostic Challenges in Celiac Disease and the Role of the Tissue Transglutaminase–Neo-Epitope

  • Torsten MatthiasEmail author
  • Sascha Pfeiffer
  • Carlo Selmi
  • M. Eric Gershwin


The diagnosis of celiac disease (CD) remains a clinical challenge based on the incomplete specificity and sensitivity rates of current non-invasive tests. Furthermore, histological assessments fail to identify all overt cases and, in particular, do not manifest pathognomonic alterations in silent cases. Accordingly, the majority of CD cases are diagnosed with great delay. Recent research into the pathogenesis of CD, allowed us to identify a neo-antigen that appears to be the most promising serological tool for the detection of anti-tissue transglutaminase as well as anti-gliadin antibodies.


Celiac disease Tissue transglutaminase Anti-gliadin antibodies 


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Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  • Torsten Matthias
    • 1
    Email author
  • Sascha Pfeiffer
    • 1
  • Carlo Selmi
    • 2
    • 3
  • M. Eric Gershwin
    • 3
  1. 1.AESKU.KIPP InstituteWendelsheimGermany
  2. 2.Department of Internal Medicine, IRCCS Istituto Clinico HumanitasUniversity of MilanMilanItaly
  3. 3.Division of Rheumatology, Allergy, and Clinical ImmunologyUniversity of CaliforniaDavisUSA

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