Clinical Reviews in Allergy & Immunology

, Volume 38, Issue 2–3, pp 287–291 | Cite as

Infectious Aspects and the Etiopathogenesis of Rheumatoid Arthritis

  • Michal Kasher Meron
  • Howard Amital
  • Daniel Shepshelovich
  • Ori Barzilai
  • Maya Ram
  • Juan-Manuel Anaya
  • Roberto Gerli
  • Bizzaro Nicola
  • Yehuda ShoenfeldEmail author


Infections are believed to contribute to the maturation of the immune system from the innate to the adaptive phases and therefore may take part in the induction of autoimmune conditions. In the current study, we present an extensive analysis conducted on sera samples of patients with rheumatoid arthritis in order to seek evidence of previous or coexisting infectious processes using the Bio-Rad BioPlex immunoassay analyzer. We detected higher rates of serological evidence of infections with Epstein–Barr virus and cytomegalovirus viruses. Our findings may indicate a role of these viruses in the pathogenesis of RA.


Rheumatoid arthritis Syphilis Toxoplasmosis Epstein–Barr virus Cytomegalovirus 


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Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  • Michal Kasher Meron
    • 1
  • Howard Amital
    • 1
  • Daniel Shepshelovich
    • 2
  • Ori Barzilai
    • 2
  • Maya Ram
    • 2
  • Juan-Manuel Anaya
    • 3
  • Roberto Gerli
    • 4
  • Bizzaro Nicola
    • 5
  • Yehuda Shoenfeld
    • 2
    • 6
    Email author
  1. 1.Department of Medicine ‘D’Meir Medical Center affiliated with Tel Aviv University Sackler Faculty of MedicineKfar-SabaIsrael
  2. 2.Department of Internal Medicine B, Center for Autoimmune Diseases affiliated with Tel Aviv University Sackler Faculty of MedicineSheba Medical CenterTel HashomerIsrael
  3. 3.Cellular Biology and Immunogenetics Unit, Corporación para Investigaciones BiológicasUniversidad del RosarioMedellinColombia
  4. 4.Rheumatology Unit, Department of Clinical and Experimental MedicineUniversity of PerugiaPerugiaItaly
  5. 5.Laboratorio di Patologia ClinicaDonà di PiaveItaly
  6. 6.Laura Schwarz-KippTel Aviv UniversityTel AvivIsrael

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