Clinical Reviews in Allergy & Immunology

, Volume 34, Issue 3, pp 321–325

Anti-α-Actinin Antibodies Cross-react with Anti-ssDNA Antibodies in Active Autoimmune Hepatitis

  • Yves Renaudineau
  • Geogios N. Dalekos
  • Paul Guéguen
  • Kalliopi Zachou
  • Pierre Youinou
Article

Abstract

Recently, we have observed that the association of anti-F-actin autoantibodies (Abs) with anti-α-actinin Abs (double reactivity) was correlated with liver disease activity in autoimmune hepatitis type 1 (AIH-1; Guéguen et al., J Clin Immunol 26:495–505, 2006). As anti-α-actinin Abs are also associated with anti-single-stranded (ss) DNA in 16 of 50 (32%) AIH-1 patients, compared with 16 of 401 (4.0%) liver disease control patients, we sought to characterize these Abs in AIH-1. When associated, anti-ssDNA Abs cross-react with anti-α-actinin Abs, but neither with anti-double-stranded DNA Abs nor with anti-F-actin Abs. Furthermore, anti-α-actinin Abs are associated with high-avidity anti-ssDNA Abs in AIH-1. In addition, double reactivity against α-actinin and ssDNA was correlated with clinical and histological activity of the disease and untreated AIH-1 patients.

Keywords

Autoimmune hepatitis type 1 Anti-DNA Anti-α-actinin 

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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Yves Renaudineau
    • 1
  • Geogios N. Dalekos
    • 2
  • Paul Guéguen
    • 1
  • Kalliopi Zachou
    • 2
  • Pierre Youinou
    • 1
    • 3
  1. 1.Brest University Medical School HospitalBrest CedexFrance
  2. 2.Thessaly University Medical SchoolLarissaGreece
  3. 3.Laboratory of ImmunologyBrest University Medical School HospitalBrest CedexFrance

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