The Role of CD4+CD25+ T Regulatory Cells in Autoimmune Diseases
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- Toubi, E. Clinic Rev Allerg Immunol (2008) 34: 338. doi:10.1007/s12016-007-8043-0
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Among the several mechanisms that play role in maintaining peripheral self-tolerance is the existence of a unique CD4+CD25+ population of naturally occurring regulatory T (Treg) cells that actively prevent both the activation and the effector function of autoreactive T cells that have escaped different mechanisms of tolerance. Many studies have shown the benefit of targeting this cell population by restoring self-tolerance. Therapies that could possibly increase the suppressive ability of T regulatory cells were proven to improve that course of autoimmune diseases.