Clinical Reviews in Allergy & Immunology

, Volume 34, Issue 1, pp 4–10 | Cite as

Antibodies to Citrullinated Vimentin are a Specific and Sensitive Marker for the Diagnosis of Rheumatoid Arthritis

  • Hannah Poulsom
  • Peter J. CharlesEmail author



The last 5 years have seen the emergence and establishment of antibodies to citrullinated antigens as the diagnostic marker for rheumatoid arthritis (RA). Initially, these were detected using a synthetic peptide, which has undergone a number of modifications to give a diagnostic test with a sensitivity of 65–80% and a specificity of >95%. Antibodies to citrullinated vimentin were first described in 1994 as a highly specific marker for RA (anti-Sa). However, no easily performed assay for these antibodies has been available.


We have examined the use of a ELISA-based assay with a mutated citrullinated vimentin (MCV) antigen (Orgentec, Mainz, Germany) to assess the diagnostic and prognostic utility of this antibody in RA.


Antibodies to MCV were detected in the sera of 74% RA patients (specificity 96%), 2% systemic lupus erythematosus, 14% Sjögren’s syndrome, and 2% scleroderma. Anti-MCV was not detected in sera from healthy blood donors. There was no difference in the frequency of antibodies detected in RA patients with early (<2 years) or chronic (>2 years) disease. There was no significant variation in anti-MCV antibody concentrations in early RA patients over a 52-week period. No significant change was observed with time between the two treatment groups of methotrexate alone or methotrexate plus infliximab.


Antibodies to MCV are a specific and sensitive marker for the diagnosis of RA.


Mutated citrullinated vimentin Anti-MCV Autoantibodies Rheumatoid arthritis 


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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  1. 1.Division of ImmunologyHammersmith Hospitals NHS TrustLondonUK
  2. 2.Kennedy Institute of RheumatologyImperial CollegeLondonUK
  3. 3.Division of ImmunologyCharing Cross HospitalLondonUK

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