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Clinical Reviews in Allergy & Immunology

, Volume 33, Issue 1–2, pp 45–56 | Cite as

Immunopathogenesis of Psoriasis

  • Brian J. Nickoloff
  • Jian-Zhong Qin
  • Frank O. Nestle
Article

Abstract

Investigations into the cause and treatment of psoriasis remain at the forefront of basic and applied clinical research efforts around the world. The purpose for this review is to provide an up-to-date synopsis of recent progress in ten sections exploring the immunological and inflammatory basis for psoriasis. Given the breadth of this topic in investigative skin biology and frequent paradigm shifts, it should not be surprising that the bibliography contains more than 150 references; many of which have been published in the last 5 years. Whereas considerable progress has been made into the immunopathogenesis of psoriasis, many fundamentally important questions remain regarding the role of cells located in both epidermal and dermal compartments. Attempts to characterize various animal models of psoriasis, delineation of the mechanism of action for biological agents, and consideration of molecular links between skin inflammation and various extracutaneous comorbidities are likely to continue challenging investigators and clinicians for many years to come.

Keywords

Psoriasis Immunopathogenesis Epidermal compartment Dermal compartment 

Notes

Acknowledgements

The authors would like to thank Ms. Lynn Walter for the valuable assistance in preparing the text and figure. This work was supported in part by NIH grant AR40065 (BJN, FON) and Wellcome Trust Grant (FON).

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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Brian J. Nickoloff
    • 1
    • 2
  • Jian-Zhong Qin
    • 1
  • Frank O. Nestle
    • 3
  1. 1.Department of PathologyLoyola University Medical CenterMaywoodUSA
  2. 2.Oncology InstituteCardinal Bernardin Cancer Center, Loyola University Medical CenterMaywoodUSA
  3. 3.St. John’s Institute of Dermatology, Division of Genetics and Molecular MedicineKings College London School of MedicineLondonUK

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