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Evolving Definition of Adult Stem/Progenitor Cells

  • Deepa BhartiyaEmail author
  • Subhan Ali Mohammad
  • Ahona Guha
  • Pushpa Singh
  • Diksha Sharma
  • Ankita Kaushik
Article
  • 19 Downloads

Sir

Adult stem cells (ASCs) comprise a rare population of cells that are expected to be (i) quiescent (ii) undergo asymmetric cell divisions (ACD) to self-renew and give rise to tissue committed ‘progenitors’ and (iii) exhibit ‘plasticity’ implying the ability to differentiate into different lineages. Unlike embryonic stem cells which are ‘immortal’, can differentiate into 200 odd cell types and are defined by their origin (inner cell mass of the blastocyst), ASCs share no such definitive means of characterization, are set aside during development, are lineage restricted and are restrained from proliferation/differentiation by their tissue-specific niche/microenvironment. Clonal expansion is another property of stem cells which implies that they can give rise to a sphere of cells by rapid proliferation and incomplete cytokinesis resulting in the formation of spheres like mammosphere, neurosphere, cardiosphere etc. As a result, two distinct populations comprising quiescent and actively...

Notes

Acknowledgements

Contributions of all working in the field is acknowledged.

Funding

Author acknowledges financial support from Indian Council of Medical Research Government of India, New Delhi, INDIA.

Compliance with Ethical Standards

Conflict of Interest

Authors declare no conflicts of interest.

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Stem Cell Biology DepartmentICMR-National Institute for Research in Reproductive HealthMumbaiIndia

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