Impact of Diabetes Mellitus on Human Mesenchymal Stromal Cell Biology and Functionality: Implications for Autologous Transplantation

  • Marwa Mahmoud
  • Nourhan Abu-Shahba
  • Osama Azmy
  • Nagwa El-BadriEmail author


Multipotent mesenchymal stem/stromal cells (MSCs) have regenerative and immunomodulatory properties to restore and repair injured tissues, making them attractive candidates for cell-based therapies. Experimental and clinical evidence has demonstrated the effectiveness of MSC transplantation in managing diabetes mellitus (DM). Autologous MSCs are assumed to be favorable because patient-derived cells are readily available and do not entail sustained immunosuppressive therapy. DM is associated with hyperglycemia, oxidative stress and altered immune responses and inflammation. It may thus alter the biological characteristics and therapeutic qualities of human MSCs (hMSCs). Several studies have explored the effect of DM or the diabetic microenvironment on the engraftment and efficacy of transplanted MSCs, which are determined by proliferation, differentiation, senescence, angiogenesis supportive effect, migration, anti-oxidative capacity and immunomodulatory properties. This review aims to present the available data on how DM impacts MSC biology and functionality and identify future perspectives for autologous MSC-based therapy in diabetics.


Diabetes mellitus Mesenchymal stromal cells Biology Functionality Autologus transplantation 



This manuscript was funded in part by the Science and Technology Development Fund, STDF grant #5300, Center of Excellence for Stem Cells and Regenerative Medicine.

Compliance with Ethical Standards

Conflict of Interest

Authors declare no conflict of interest.

Supplementary material

12015_2018_9869_MOESM1_ESM.docx (18 kb)
ESM 1 (DOCX 17 kb)


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Stem Cell Research group, Medical Research Centre of ExcellenceNational Research CentreCairoEgypt
  2. 2.Medical Molecular Genetics Department, Human Genetics and Genome Research DivisionNational Research CentreCairoEgypt
  3. 3.Department of Reproductive Health ResearchNational Research CentreCairoEgypt
  4. 4.Center of Excellence for Stem Cells and Regenerative MedicineZewail City of Science and Technology6th of October CityEgypt

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