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Long Noncoding RNAs: New Players in the Osteogenic Differentiation of Bone Marrow- and Adipose-Derived Mesenchymal Stem Cells

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Abstract

Mesenchymal stem cells (MSCs) are an important population of multipotent stem cells that differentiate into multiple lineages and display great potential in bone regeneration and repair. Although the role of protein-coding genes in the osteogenic differentiation of MSCs has been extensively studied, the functions of noncoding RNAs in the osteogenic differentiation of MSCs are unclear. The recent application of next-generation sequencing to MSC transcriptomes has revealed that long noncoding RNAs (lncRNAs) are associated with the osteogenic differentiation of MSCs. LncRNAs are a class of non-coding transcripts of more than 200 nucleotides in length. Noncoding RNAs are thought to play a key role in osteoblast differentiation through various regulatory mechanisms including chromatin modification, transcription factor binding, competent endogenous mechanism, and other post-transcriptional mechanisms. Here, we review the roles of lncRNAs in the osteogenic differentiation of bone marrow- and adipose-derived stem cells and provide a theoretical foundation for future research.

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Acknowledgements

This study was financially supported by grants from the National Natural Science Foundation of China (Nos. 81670957, 81772876, and 81700938), a grant from the Peking University (PKU) School and Hospital of Stomatology (No. PKUSS20140104), and seed grants from the PKU School of Stomatology for PostDoc (No. YS0203) and the Beijing Natural Science Foundation (No. 7172239).

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  1. Department of Orthodontics, Peking University School and Hospital of Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing, 100081, People’s Republic of China

    Qiaolin Yang, Xiaobei Li, Runzhi Guo, Yiping Huang, Yunfei Zheng & Weiran Li

  2. Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, People’s Republic of China

    Lingfei Jia

  3. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, 100081, People’s Republic of China

    Lingfei Jia

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  1. Qiaolin Yang
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Yang, Q., Jia, L., Li, X. et al. Long Noncoding RNAs: New Players in the Osteogenic Differentiation of Bone Marrow- and Adipose-Derived Mesenchymal Stem Cells. Stem Cell Rev and Rep 14, 297–308 (2018). https://doi.org/10.1007/s12015-018-9801-5

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