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Stem Cell Reviews and Reports

, Volume 14, Issue 1, pp 1–12 | Cite as

Mesenchymal Stem Cells (MSCs) Therapy for Recovery of Fertility: a Systematic Review

  • Zahra FazeliEmail author
  • Atieh Abedindo
  • Mir Davood Omrani
  • Sayyed Mohammad Hossein Ghaderian
Article

Abstract

In recent years, the mesenchymal stem cells (MSCs) have provided the new opportunities to treat different disorders including infertility. Different studies have suggested that the MSCs have ability to differentiate into germ-like cells under specific induction conditions as well as transplantation to gonadal tissues. The aim of this systematic review was to evaluate the results obtained from different studies on MSCs therapy for promoting fertility. This search was done in PubMed and Science Direct databases using key words MSCs, infertility, therapy, germ cell, azoospermia, ovarian failure and mesenchymal stem cell. Among the more than 11,400 papers, 53 studies were considered eligible for more evaluations. The obtained results indicated that the most studies were performed on MSCs derived from bone marrow and umbilical cord as compared with the other types of MSCs. Different evaluations on animal models as well as in vitro studies supported from their role in the recovery of spermatogenesis and folliculogenesis. Although the data obtained from this systematic review are promising, but the further studies need to assess the efficiency and safety of transplantation of these cells in fertility recovery.

Keywords

Stem cell therapy Mesenchymal stem cell Infertility Treatment 

Notes

Compliance with Ethical Standards

Funding

This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Zahra Fazeli
    • 1
    Email author
  • Atieh Abedindo
    • 1
  • Mir Davood Omrani
    • 1
    • 2
  • Sayyed Mohammad Hossein Ghaderian
    • 1
    • 2
  1. 1.Department of Medical Genetics, Faculty of MedicineShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Urogenital Stem Cell Research CenterShahid Beheshti University of Medical SciencesTehranIran

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