Stem Cell Reviews and Reports

, Volume 13, Issue 3, pp 347–363 | Cite as

Anti-Cancer Drug Validation: the Contribution of Tissue Engineered Models

  • Mariana R. Carvalho
  • Daniela Lima
  • Rui L. Reis
  • Joaquim M. Oliveira
  • Vitor M. Correlo
Article

Abstract

Drug toxicity frequently goes concealed until clinical trials stage, which is the most challenging, dangerous and expensive stage of drug development. Both the cultures of cancer cells in traditional 2D assays and animal studies have limitations that cannot ever be unraveled by improvements in drug-testing protocols. A new generation of bioengineered tumors is now emerging in response to these limitations, with potential to transform drug screening by providing predictive models of tumors within their tissue context, for studies of drug safety and efficacy. Considering the NCI60, a panel of 60 cancer cell lines representative of 9 different cancer types: leukemia, lung, colorectal, central nervous system (CNS), melanoma, ovarian, renal, prostate and breast, we propose to review current “state of art” on the 9 cancer types specifically addressing the 3D tissue models that have been developed and used in drug discovery processes as an alternative to complement their study.

Keywords

Cancer Tissue engineering Biomaterials 3D Drug discovery 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Mariana R. Carvalho
    • 1
    • 2
  • Daniela Lima
    • 1
    • 2
  • Rui L. Reis
    • 1
    • 2
  • Joaquim M. Oliveira
    • 1
    • 2
  • Vitor M. Correlo
    • 1
    • 2
  1. 1.3B’s Research Group - Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoGuimarãesPortugal
  2. 2.ICVS/3B’s - PT Government Associate LaboratoryBraga/GuimarãesPortugal

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