Stem Cell Reviews and Reports

, Volume 13, Issue 1, pp 68–78 | Cite as

Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem Cells

  • Carlos D. LuzzaniEmail author
  • Santiago G. MiriukaEmail author


Mesenchymal stem cells (MSC) have been extensively studied over the past years for the treatment of different diseases. Most of the ongoing clinical trials currently involve the use of MSC derived from adult tissues. This source may have some limitations, particularly with therapies that may require extensive and repetitive cell dosage. However, nowadays, there is a staggering growth in literature on a new source of MSC. There is now increasing evidence about the mesenchymal differentiation from pluripotent stem cell (PSC). Here, we summarize the current knowledge of pluripotent-derived mesenchymal stem cells (PD-MSC). We present a historical perspective on the subject, and then discuss some critical questions that remain unanswered.


Pluripotent stem cells Embryonic stem cells Cell reprogramming Mesenchymal stem cells Mesenchymal stromal cells Differentiation Pluripotent-derived mesenchymal stem cells iPS-derived mesenchymal stem cells Epithelial-to-mesenchymal transition EMT 



Bone marrow-derived mesenchymal stem cells


Epithelial-to-mesenchymal transition


induced pluripotent stem cells


Mesenchymal stem cells


Pluripotent-derived mesenchymal stem cells


Plurpotent stem cells



This work is possible thanks to supporting grants from CONICET (PIP-112-20150100723) and FONCYT (PID-2014-0052, PICT-2015-1469, PICT-2015-0868, y PICT-2015-3850). We thank Fundación FLENI and Fundación Pérez Companc for their support.

Compliance with Ethical Standards

Conflict of interests

The authors declare that they have no conflict of interest.


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© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.LIAN-CONICET - FLENIBuenos AiresArgentina
  2. 2.Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)Buenos AiresArgentina

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