Stem Cell Reviews and Reports

, Volume 12, Issue 6, pp 708–720 | Cite as

Epigenetic Control of Reprogramming and Transdifferentiation by Histone Modifications

  • Hua Qin
  • Andong Zhao
  • Cuiping Zhang
  • Xiaobing FuEmail author


Somatic cells can be reprogrammed to pluripotent stem cells or transdifferentiate to another lineage cell type. Much efforts have been made to unravel the epigenetic mechanisms underlying the cell fate conversion. Histone modifications as the major epigenetic regulator are implicated in various aspects of reprogramming and transdifferentiation. Here, we discuss the roles of histone modifications on reprogramming and transdifferentiation and hopefully provide new insights into induction and promotion of the cell fate conversion by modulating histone modifications.


Somatic cells iPSCs Reprogramming Transdifferentiation Histone modifications Epigenetic Cell fate conversion 



This research was supported in part by the National Nature Science Foundation of China (81230041, 81421064) and the National Basic Science and Development Program (973 Program, 2012CB518105). There is no conflict of interest declared by any of the authors.

Compliance with Ethical Standards

Conflicts of Interest

The authors indicate no potential conflicts of interest.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Hua Qin
    • 1
  • Andong Zhao
    • 1
  • Cuiping Zhang
    • 2
  • Xiaobing Fu
    • 2
    Email author
  1. 1.Tianjin Medical UniversityTianjinChina
  2. 2.Key Laboratory of Wound Repair and Regeneration of PLAThe First Hospital Affiliated to the PLA General HospitalBeijingChina

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