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Stem Cell Reviews and Reports

, Volume 11, Issue 2, pp 205–218 | Cite as

Pluripotent Stem Cells for Schwann Cell Engineering

Article

Abstract

Tissue engineering of Schwann cells (SCs) can serve a number of purposes, such as in vitro SC-related disease modeling, treatment of peripheral nerve diseases or peripheral nerve injury, and, potentially, treatment of CNS diseases. SCs can be generated from autologous stem cells in vitro by recapitulating the various stages of in vivo neural crest formation and SC differentiation. In this review, we survey the cellular and molecular mechanisms underlying these in vivo processes. We then focus on the current in vitro strategies for generating SCs from two sources of pluripotent stem cells, namely embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Different methods for SC engineering from ESCs and iPSCs are reviewed and suggestions are proposed for optimizing the existing protocols. Potential safety issues regarding the clinical application of iPSC-derived SCs are discussed as well. Lastly, we will address future aspects of SC engineering.

Keywords

Induced pluripotent stem cells iPSC Schwann cell Peripheral nerve Myelination Mesenchymal stem cells Reprogramming Differentiation Neural crest 

Notes

Conflict of Interest

The authors declare no potential conflict of interests

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Neuroscience, Section Medical Physiology, University Medical Center GroningenUniversity of GroningenGroningenThe Netherlands

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