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Stem Cell Reviews and Reports

, Volume 9, Issue 1, pp 65–79 | Cite as

Multipotent Mesenchymal Stromal Cell Therapy and Risk of Malignancies

  • Federica Casiraghi
  • Giuseppe Remuzzi
  • Mauro Abbate
  • Norberto Perico
Article

Abstract

Cell therapy with Multipotent Mesenchymal Stromal Cells (MSC) holds enormous promise for the treatment of a large number of degenerative and immune/inflammatory diseases. Their multilineage differentiation potential, immunoprivilege and capacity of promoting recovery of damaged tissues coupled with anti-inflammatory and immunosuppressive properties are the focus of a multitude of clinical studies currently underway. The recognized clinical potential of MSC repairing/immunomodulatory effects now encompasses graft-versus-host disease, hematologic malignancies, cardiovascular diseases, neurologic and inherited diseases, autoimmune diseases, organ transplantation, refractory wounds, and bone/cartilage defects among others. However, it has been suggested that both the need of extensive ex vivo culture for MSC clinical use, and their proangiogenic, anti-apoptotic and immunomodulatory properties may act together as tumor promoters, raising significant safety concerns. This paper will review the available data on in vitro MSC maldifferentiation and the ability of MSC to sustain tumor growth in vivo, with the aim to clarify whether MSC-based therapeutic approaches may carry actual risk of malignancies.

Keywords

Multipotent mesenchymal stromal cells Malignant maldifferentiation Cancer Tumor Safety 

Notes

Acknowledgement

This work was supported by grants from Fondazione ART (Fondazione per la Ricerca sui Trapianti, Milan, Italy). We greatly acknowledge Drs. Martino Introna and Alessandro Rambaldi for their suggestions and helpful discussion. The authors are members of the Mesenchymal Stem Cells in Solid Organ Transplantation (MISOT) study group, www.misot.de.

Part of the research leading to this work has received funding from the European Community under the European Community’s Seventh Framework Programme (FP7/2007-2013), grant number 223007, STAR-T REK project.

Conflict of Interest

The authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Federica Casiraghi
    • 1
    • 2
  • Giuseppe Remuzzi
    • 1
  • Mauro Abbate
    • 1
  • Norberto Perico
    • 1
  1. 1.Transplant Research Center “Chiara Cucchi de Alessandri e Gilberto Crespi”, Department of Immunology and TransplantationOspedali Riuniti – Mario Negri Institute for Pharmacological ResearchBergamoItaly
  2. 2.Transplant Research Center “Chiara Cucchi de Alessandri e Gilberto Crespi”Mario Negri Institute for Pharmacological ResearchRanicaItaly

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