Stem Cell Reviews and Reports

, Volume 8, Issue 1, pp 243–250 | Cite as

The Role of Chemokines in Mesenchymal Stem Cell Homing to Myocardium

Article

Abstract

A growing body of preclinical evidence suggests that mesenchymal stem cells (MSCs) are effective for the structural and functional recovery of the infracted heart. Accordingly, clinical trials are underway to determine the benefit of MSC-based therapies. While systemic administration of MSCs is an attractive strategy, and is the route currently used for the administration of MSCs in clinical studies for myocardial infarction, the majority of infused cells do not appear to localize to infracted myocardium in animal studies. Recently, important progress has been made in identifying chemokine receptors critical for the migration and homing of MSCs. Here, we review recent literature regarding mechanisms of MSC homing and recruitment to the ischemic myocardium, and discuss potential influences of low engraftment rates of systemically administered MSCs to the infracted heart tissue on the effects of MSC-based therapies on myocardial infarction.

Keywords

Mesenchymal stem cells Homing Chemokines CCR Myocardial infarction 

Notes

Acknowledgements

We thank Xusheng Wang and Ying Zhou for assistances in drawing graphs and collecting data. This work was supported by grants from Natural Science Foundation of China (No. 30871273, 30971496, U1032003) to Y Wu.

Disclosures

The authors indicate no potential conflicts of interest.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Life Science DivisionTsinghua University Graduate School at ShenzhenShenzhenChina
  2. 2.Center of Excellence in Tissue Engineering, Department of Cell Biology, Institute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical CollegeBeijingChina
  3. 3.Tsinghua University Graduate School at ShenzhenShenzhenChina

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