Stem Cell Reviews and Reports

, Volume 7, Issue 3, pp 488–493 | Cite as

Mammalian Cell Dedifferentiation as a Possible Outcome of Stress



Differentiation cascades are arranged hierarchically; stem cells positioned at the top of the hierarchy generate committed progenitors that, in turn, proliferate and further differentiate stepwise into mature progeny. This rigid, irreversible structure ensures the phenotypic stability of adult tissues. However, such rigidity may be problematic under conditions of tissue damage when reconstitution is required. Although it may seem unlikely that the restrictions on changes in cell phenotypes would be lifted to enable tissue reconstitution, it is nevertheless possible that mammalian tissues are endowed with sufficient flexibility to enable their adaptation to extreme conditions.


Stem cells Mammalian cells Dedifferentiation Stress Pluripotency Reprogramming Epigenetics 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Molecular Cell BiologyWeizmann Institute of ScienceRehovotIsrael

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