Stem Cell Reviews and Reports

, Volume 5, Issue 4, pp 319–327

Building a Framework for Embryonic Microenvironments and Cancer Stem Cells

  • Antonio Ruiz-Vela
  • Cristóbal Aguilar-Gallardo
  • Carlos Simón
Article

DOI: 10.1007/s12015-009-9096-7

Cite this article as:
Ruiz-Vela, A., Aguilar-Gallardo, C. & Simón, C. Stem Cell Rev and Rep (2009) 5: 319. doi:10.1007/s12015-009-9096-7

Abstract

The putative existence of a cancer stem cell niche consisting of bi-directional stromal and stem cell secreting factors that trigger cancer stem cell growth and proliferation has been hypothesized in the nervous and hematopoietic systems. In light of this theory, it has been proposed that embryonic stem cell microenvironments, upon interactions with cancer stem cells, may reprogram cancer cells resulting in a substantial inhibition of tumor cell properties. Here, we discuss emerging data that support this novel concept of cancer inhibitory factors produced in the context of embryonic microenvironments as well as by embryonic stem cells (ESCs).

Keywords

Embryonic stem cells Cancer stem cell Niches Microenvironment Reprogramming 

Copyright information

© Springer Science + Business Media 2009

Authors and Affiliations

  • Antonio Ruiz-Vela
    • 1
  • Cristóbal Aguilar-Gallardo
    • 1
  • Carlos Simón
    • 1
    • 2
  1. 1.Valencia Node of the Spanish Stem Cell Bank, Prince Felipe Research Center (CIPF)ValenciaSpain
  2. 2.Fundación IVI-Instituto Universitario IVIValencia UniversityValenciaSpain

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