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Stem Cell Reviews and Reports

, Volume 5, Issue 4, pp 301–314 | Cite as

Consensus Guidance for Banking and Supply of Human Embryonic Stem Cell Lines for Research Purposes

  • The International Stem Cell Banking Initiative
Translational Stem Cell Studies

Background and Scope

In just a few years hundreds of human embryonic stem cell (hESC) lines have been established in laboratories around the world and many programmes of research initiated to investigate their properties and broad ranging potential in therapy and for other research applications, such as developmental biology, toxicology and drug discovery. This work is being performed with a variety of cell lines using a variety of culture conditions; a situation that makes standardisation between projects and publications very difficult and could prevent the identification of cells that have undergone permanent deleterious changes. Clearly the consequence of using such cells would be wasted time and resources but, more seriously, the generation of erroneous data in the literature which could both confuse and delay scientific progress in this area. Thus ensuring that cell lines used in this dynamic field have the correct identity and characteristics is critical to the delivery of...

Keywords

Human embryonic stem cells Cell banking Standardisation Microbiological testing Pluripotency Quality control 

Notes

Acknowledgements

We would like to thank the International Stem Cell Forum for funding this initiative. Details of the ‘Forum’ can be found at www.stemcellforum.org. Thanks also to the Jackson Laboratory (Bar Harbor, Maine, USA) who hosted meetings of the International Stem Cell Banking Initiative to establish this guidance and to Mrs Gill Cathro who assisted in the preparation of these meetings.

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Copyright information

© Humana Press 2009

Authors and Affiliations

  • The International Stem Cell Banking Initiative
    • 1
  1. 1.Blanche LaneRidgeUK

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