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Stem Cell Reviews

, Volume 4, Issue 2, pp 101–112 | Cite as

Therapeutic Potential of Adult Bone Marrow Stem Cells in Liver Disease and Delivery Approaches

  • You Qing Xu
  • Zun Chang Liu
Article

Abstract

Hematopoietic stem cells (HSCs) and mesenchymal stem cell (MSCs) are two main subtypes of bone marrow stem cells. Extensive studies have been carried out to investigate the therapeutic potential of BMSCs in liver disease. A number of animal and human studies demonstrated that either HSCs or MSCs could be applied to therapeutic purposes in certain liver diseases. The diseased liver may recruit migratory stem cells, particularly from the bone marrow, to generate hepatocyte-like cells either by transdifferentiation or cell fusion. Transplantation of BMSCs has therapeutic effects of restoration of liver mass and function, alleviation of fibrosis and correction of inherited liver diseases. There are still controversial results over the potential effects of BMSCs on liver diseases, and some of the discrepancies are thought to be lied in the differences of experimental protocols, differences in individual research laboratory, and the uncertainties of the techniques employed. Several potential approaches for BMSCs delivery in liver diseases have been proposed in animal studies and human trials. BMSCs can be delivered via intraportal vein, systemic infusion, intraperitoneal, intrahepatic, intrasplenic. The optimal stem cells delivery should be easy to perform, less invasive and traumatic, minimum side effects, and with high cells survival rate. In this review, we focus on the up-to-date evidence of therapeutic effects of BMSCs on liver disease, the characteristics of various delivery approaches, and the considerations for future studies.

Keywords

Bone marrow stem cells Liver disease Delivery Haematopoietic stem cells Mesenchymal stem cells 

Abbreviations

BMSCs

bone marrow stem cells

HSCs

hematopoietic stem cells

MSCs

mesenchymal stem cells

AA

allylalcohol

Cl4

carbon tetrachloride

F344

Nagase analbuminemic rat

FAH

fumarylacetoacetate hydrolase

G-CSF

granulocyte colony-stimulating factor

MMP-9

matrix metalloproteinase 9

HGF

hepatocyte growth factor

SDF-1

stromal cell-derived factor-1

FISH

fluorescence in situ hybridization

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Copyright information

© Humana Press 2008

Authors and Affiliations

  1. 1.Department of Gastroenterology, Beijing Tiantan HospitalCapital Medical UniversityBeijingChina
  2. 2.Artificial Cells and Organs Research CenterMcGill UniversityMontrealCanada

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