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Recent Advances of Gold Nanoparticles in Biomedical Applications: State of the Art

  • Negar Sedghi Aminabad
  • Masoud Farshbaf
  • Abolfazl AkbarzadehEmail author
Review Paper
  • 97 Downloads

Abstract

Nanomedicine is one of the growing fields that presents new techniques for cancer diagnosis and treatment. Gold nanoparticles (GNPs) are considered as an important class of nanomaterials that possess superior physicochemical properties that make them valuable in medical applications. Unique optical properties of GNPs and their utility in photothermal and radiotherapy have extended a new platform for early detection and treatment of cancer, lately. Nanostructures based on GNPs are nontoxic and biocompatible with a large surface area that makes it possible to modify their surface with different chemicals including different polymers, antibodies, and even drug molecules. Therefore, they are utilized for targeted drug delivery in order to carry drugs and selectively release them in desired tissues which reduces destructive effects on healthy cells while it elevates the drug dose in cancerous ones. This review mainly covers the basic properties of GNPs, their synthesis methods, and focuses on surface modification of these nanoparticles and their diagnosis and therapeutic applications in cancer.

Keywords

Gold nanoparticles Cancer therapy Surface plasmon resonance Imaging Photothermal therapy 

Notes

Acknowledgements

This work is funded by the 2017 Biotechnology Research Center, Tabriz University of Medical Sciences Grant. The authors would like to express their appreciation to Soodabeh Davaran and Ebrahim Mostafavi for their kind support and assistance with this review.

Author contributions

A.A. and M.F. conceived the study and participated in its design and coordination. N.S.A. participated in the sequence alignment and drafted the manuscript. S.D. and E.M. revised the manuscript. All authors read and approved the final manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Xu, X., Ho, W., Zhang, X., Bertrand, N., & Farokhzad, O. (2015). Cancer nanomedicine: from targeted delivery to combination therapy, (in Eng). Trends in Molecular Medicine, 21(4), 223–32.PubMedPubMedCentralGoogle Scholar
  2. 2.
    Wicki, A., Witzigmann, D., Balasubramanian, V., & Huwyler, J. (2015). Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications. Journal of Controlled Release, 200(Supplement C), 138–157.PubMedGoogle Scholar
  3. 3.
    Panahi, Y. et al. (2017). Preparation, surface properties, and therapeutic applications of gold nanoparticles in biomedicine, (in Eng). Drug Research (Stuttgart), 11(02), 77–87.Google Scholar
  4. 4.
    Chhour, P. et al. (2016). Labeling monocytes with gold nanoparticles to track their recruitment in atherosclerosis with computed tomography. Biomaterials, 87, 93–103.PubMedPubMedCentralGoogle Scholar
  5. 5.
    Fratoddi, I., Venditti, I., Cametti, C., & Russo, M. V. (2015). How toxic are gold nanoparticles? The state-of-the-art. Nano Research, 8(6), 1771–1799.Google Scholar
  6. 6.
    Cruje, C., & Chithrani, B. D. (2015). Integration of peptides for enhanced uptake of PEGylayed gold nanoparticles. Journal of Nanoscience and Nanotechnology, 15(3), 2125–2131.PubMedGoogle Scholar
  7. 7.
    Mieszawska, A. J., Mulder, W. J., Fayad, Z. A., & Cormode, D. P. (2013). Multifunctional gold nanoparticles for diagnosis and therapy of disease. Molecular Pharmaceutics, 10(3), 831–847.PubMedPubMedCentralGoogle Scholar
  8. 8.
    Yameen, B., Choi, W. I., Vilos, C., Swami, A., Shi, J., & Farokhzad, O. C. (2014). Insight into nanoparticle cellular uptake and intracellular targeting. Journal of Controlled Release, 190, 485–499.PubMedPubMedCentralGoogle Scholar
  9. 9.
    Locatelli, E. (2014). Synthesis and surface modification of silver and gold nanoparticles. Nanomedicine applications against Glioblastoma Multiforme. Alma Mater Studiorumalma. 109.Google Scholar
  10. 10.
    Yeh, Y.-C., Creran, B., & Rotello, V. M. (2012). Gold nanoparticles: preparation, properties, and applications in bionanotechnology. Nanoscale, 4(6), 1871–1880.PubMedGoogle Scholar
  11. 11.
    Huang, X., & El-Sayed, M. A. (2010). Gold nanoparticles: optical properties and implementations in cancer diagnosis and photothermal therapy. Journal of Advanced Research, 1(1), 13–28.Google Scholar
  12. 12.
    Amendola, V., Pilot, R., Frasconi, M., Maragò, O. M., & Iatì, M. A. (2017). Surface plasmon resonance in gold nanoparticles: a review. Journal of Physics: Condensed Matter, 29(20), 203002.PubMedGoogle Scholar
  13. 13.
    Cheng, S., Hideshima, S., Kuroiwa, S., Nakanishi, T., & Osaka, T. (2015). Label-free detection of tumor markers using field effect transistor (FET)-based biosensors for lung cancer diagnosis. Sensors and Actuators B: Chemical, 212, 329–334.Google Scholar
  14. 14.
    Amendola, V. et al. (2014). Physico-chemical characteristics of gold nanoparticles. In R. Gonzalo, A. Sánchez (Ed.) Comprehensive analytical chemistry, vol. 66 (pp. 81−152). Elsevier: United States of America.Google Scholar
  15. 15.
    Cunningham, A., & Bürgi, T. (2013). Bottom-up organisation of metallic nanoparticles. In C. Rockstuhl, T. Scharf, (eds.) Amorphous nanophotonics. (pp. 1–37). Berlin, Germany: Springer.Google Scholar
  16. 16.
    Shah, M., et al. (2014). Gold nanoparticles: various methods of synthesis and antibacterial applications. Frontiers in Bioscience, 19(1320), 10.2741.Google Scholar
  17. 17.
    Singh, M., Manikandan, S., & Kumaraguru, A. (2011). Nanoparticles: a new technology with wide applications. Research Journal of Nanoscience and Nanotechnology, 1(1), 1–11.Google Scholar
  18. 18.
    Zare, D., Akbarzadeh, A., & Bararpour, N. (2010). Synthesis and functionalization of gold nanoparticles by using of poly functional amino acids. International Journal of Nanoscience and Nanotechnology, 6(4), 223–230.Google Scholar
  19. 19.
    Mieszawska, A. J., Mulder, W. J. M., Fayad, Z. A., & Cormode, D. P., "Multifunctional Gold Nanoparticles for Diagnosis and Therapy of Disease," Molecular Pharmaceutics, vol. 10, no. 3, pp. 831-847, 2013/03/04 2013.Google Scholar
  20. 20.
    Herizchi, R., Abbasi, E., Milani, M., & Akbarzadeh, A. (2016). Current methods for synthesis of gold nanoparticles, (in Eng). Artificial Cells, Nanomedicine, and Biotechnology, 44(2), 596–602.PubMedGoogle Scholar
  21. 21.
    Li, Y. (2011). Mechanistic insight into the Brust-Schiffrin two-phase method for organochalcogenate-protected metal nanoparticles. Georgetown University, Department of Chemistry.Google Scholar
  22. 22.
    Piella, J., Bastús, N. G., & Puntes, V. (2016). Size-controlled synthesis of sub-10-nanometer citrate-stabilized gold nanoparticles and related optical properties. Chemistry of Materials, 28(4), 1066–1075.Google Scholar
  23. 23.
    Carbó-Argibay, E., & Rodríguez-González, B. (2016). Controlled growth of colloidal gold nanoparticles: single-crystalline versus multiply-twinned particles. Israel Journal of Chemistry, 56(4), 214–226.Google Scholar
  24. 24.
    Jiali, N., Tao, Z., & Zhongfan, L. (2007). One-step seed-mediated growth of 30–150 nm quasispherical gold nanoparticles with 2-mercaptosuccinic acid as a new reducing agent. Nanotechnology, 18(32), 325607.Google Scholar
  25. 25.
    Annadhasan, M., Kasthuri, J., & Rajendiran, N. (2015). Green synthesis of gold nanoparticles under sunlight irradiation and their colorimetric detection of Ni2+and Co2+ions. RSC Advances, 5(15), 11458–11468.  https://doi.org/10.1039/C4RA14034F.Google Scholar
  26. 26.
    Yu, J., Xu, D., Guan, H. N., Wang, C., Huang, L. K., & Chi, D. F. (2016). Facile one-step green synthesis of gold nanoparticles using Citrus maxima aqueous extracts and its catalytic activity. Materials Letters, 166, 110–112.Google Scholar
  27. 27.
    Maddinedi, Sb, Mandal, B. K., Ranjan, S., & Dasgupta, N. (2015). Diastase assisted green synthesis of size-controllable gold nanoparticles. RSC Advances, 5(34), 26727–26733.  https://doi.org/10.1039/C5RA03117F.Google Scholar
  28. 28.
    DeLong, R. K., Reynolds, C. M., Malcolm, Y., Schaeffer, A., Severs, T., & Wanekaya, A. (2010). Functionalized gold nanoparticles for the binding, stabilization, and delivery of therapeutic DNA, RNA, and other biological macromolecules. Nanotechnology, Science and Applications, 3, 53.PubMedPubMedCentralGoogle Scholar
  29. 29.
    Suk, J. S., Xu, Q., Kim, N., Hanes, J., & Ensign, L. M. (2016). PEGylation as a strategy for improving nanoparticle-based drug and gene delivery. Advanced Drug Delivery Reviews, 99, 28–51.PubMedGoogle Scholar
  30. 30.
    Ajnai, G., Chiu, A., Kan, T., Cheng, C.-C., Tsai, T.-H., & Chang, J. (2014). Trends of gold nanoparticle-based drug delivery system in cancer therapy. Journal of Experimental & Clinical Medicine, 6(6), 172–178.Google Scholar
  31. 31.
    Muddineti, O. S., Ghosh, B., & Biswas, S. (2015). Current trends in using polymer coated gold nanoparticles for cancer therapy. International Journal of pharmaceutics, 484(1−2), 252–267.PubMedGoogle Scholar
  32. 32.
    Chen, Y.-H., et al. (2007). Methotrexate conjugated to gold nanoparticles inhibits tumor growth in a syngeneic lung tumor model. Molecular Pharmaceutics, 4(5), 713–722.PubMedGoogle Scholar
  33. 33.
    Kumar, A., et al. (2014). Neuropilin-1-targeted gold nanoparticles enhance therapeutic efficacy of platinum (IV) drug for prostate cancer treatment. ACS Nano, 8(5), 4205–4220.PubMedGoogle Scholar
  34. 34.
    Stiufiuc, R., et al. (2013). One-step synthesis of PEGylated gold nanoparticles with tunable surface charge. Journal of Nanomaterials, 2013, 88.Google Scholar
  35. 35.
    Liu, H., et al. (2015). Control of surface ligand density on PEGylated gold nanoparticles for optimized cancer cell uptake. Particle & Particle Systems Characterization, 32(2), 197–204.Google Scholar
  36. 36.
    Conde, J., Tian, F., Baptista, P. V., & Jesús, M. (2014). Multifunctional gold nanocarriers for cancer theranostics: from bench to bedside and back again?. In M. J. Alonso, M. Garcia-Fuentes, (eds.) In Nano-Oncologicals. (pp. 295–328). Berlin, Germany: Springer.Google Scholar
  37. 37.
    Kumar, A., Boruah, B. M., & Liang, X.-J. (2011). Gold nanoparticles: promising nanomaterials for the diagnosis of cancer and HIV/AIDS. Journal of Nanomaterials, 2011, 22.Google Scholar
  38. 38.
    Raghavendra, R., Arunachalam, K., Annamalai, S. K., & Aarrthy, M. (2014). Diagnostics and therapeutic application of gold nanoparticles. Medicine (Bio Diagnostics, Drug Delivery and Cancer Therapy), 2, 4.Google Scholar
  39. 39.
    Lu, F., Doane, T. L., Zhu, J.-J., & Burda, C. (2012). Gold nanoparticles for diagnostic sensing and therapy. Inorganica Chimica Acta, 393, 142–153.Google Scholar
  40. 40.
    Cordeiro, M., Ferreira Carlos, F., Pedrosa, P., Lopez, A., & Baptista, P. V. (2016). Gold nanoparticles for diagnostics: advances towards points of care. Diagnostics, 6(4), 43.PubMedCentralGoogle Scholar
  41. 41.
    Kang, J. W., So, P. T. C., Dasari, R. R., & Lim, D.-K. (2015). High resolution live cell Raman imaging using subcellular organelle-targeting SERS-sensitive gold nanoparticles with highly narrow intra-nanogap. Nano Letters, 15(3), 1766–1772.PubMedPubMedCentralGoogle Scholar
  42. 42.
    Ma, X., et al. (2013). Graphene oxide wrapped gold nanoparticles for intracellular Raman imaging and drug delivery. Journal of Materials Chemistry B, 1(47), 6495–6500.  https://doi.org/10.1039/C3TB21385D.Google Scholar
  43. 43.
    Ma, J., Liu, Y., Gao, P. F., Zou, H. Y., & Huang, C. Z. (2016). Precision improvement in dark-field microscopy imaging by using gold nanoparticles as an internal reference: a combined theoretical and experimental study. Nanoscale, 8(16), 8729–8736.  https://doi.org/10.1039/C5NR08837B.PubMedGoogle Scholar
  44. 44.
    Jin, H.-Y., Li, D.-W., Zhang, N., Gu, Z., & Long, Y.-T. (2015). Analyzing carbohydrate–protein interaction based on single plasmonic nanoparticle by conventional dark field microscopy. ACS Applied Materials & Interfaces, 7(22), 12249–12253.Google Scholar
  45. 45.
    Qian, W., Huang, X., Kang, B., & El-Sayed, M. A. (2010). Dark-field light scattering imaging of living cancer cell component from birth through division using bioconjugated gold nanoprobes. Journal of Biomedical Optics, 15(4), 046025–046025-9.PubMedGoogle Scholar
  46. 46.
    Mallidi, S., Luke, G. P., & Emelianov, S. (2011). Photoacoustic imaging in cancer detection, diagnosis, and treatment guidance. Trends in Biotechnology, 29(5), 213–221.PubMedPubMedCentralGoogle Scholar
  47. 47.
    Li, W., & Chen, X. (2015). Gold nanoparticles for photoacoustic imaging. Nanomedicine, 10(2), 299–320.PubMedGoogle Scholar
  48. 48.
    Song, J., et al. (2016). “Smart” gold nanoparticles for photoacoustic imaging: an imaging contrast agent responsive to the cancer microenvironment and signal amplification via pH-induced aggregation. Chemical Communications, 52(53), 8287–8290.PubMedGoogle Scholar
  49. 49.
    Poon, W., Heinmiller, A., Zhang, X., & Nadeau, J. L. (2015). Determination of biodistribution of ultrasmall, near-infrared emitting gold nanoparticles by photoacoustic and fluorescence imaging. Journal of Biomedical Optics, 20(6), 066007.PubMedGoogle Scholar
  50. 50.
    Sun, I.-C., Dumani, D., & Emelianov, S. Y., "Ultrasound-guided photoacoustic imaging of lymph nodes with biocompatible gold nanoparticles as a novel contrast agent (Conference Presentation)," in Colloidal Nanoparticles for Biomedical Applications XII, 2017, vol. 10078, p. 100780E: International Society for Opticsand Photonics.Google Scholar
  51. 51.
    Kim, J., Lee, N., & Hyeon, T. (2017). Recent development of nanoparticles for molecular imaging. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 375, 2107.Google Scholar
  52. 52.
    Na, H. B., Song, I. C., & Hyeon, T. (2009). Inorganic nanoparticles for MRI contrast agents. Advanced Materials, 21(21), 2133–2148.Google Scholar
  53. 53.
    Meir, R., et al. (2015). Nanomedicine for cancer immunotherapy: tracking cancer-specific T-cells in vivo with gold nanoparticles and CT imaging. ACS Nano, 9(6), 6363–6372.PubMedGoogle Scholar
  54. 54.
    Cao, Y., et al. (2015). Targeted CT imaging of human hepatocellular carcinoma using low-generation dendrimer-entrapped gold nanoparticles modified with lactobionic acid. Journal of Materials Chemistry B, 3(2), 286–295.  https://doi.org/10.1039/C4TB01542H.Google Scholar
  55. 55.
    Lorusso, D., Bria, E., Costantini, A., Di Maio, M., Rosti, G., & Mancuso, A. (2017). Patients’ perception of chemotherapy side effects: Expectations, doctor–patient communication and impact on quality of life–An Italian survey. European Journal of Cancer Care, 26(2), e12618.Google Scholar
  56. 56.
    Kumar, A., Zhang, X., & Liang, X.-J. (2013). Gold nanoparticles: emerging paradigm for targeted drug delivery system. Biotechnology Advances, 31(5), 593–606.PubMedGoogle Scholar
  57. 57.
    Ghosh, P., Han, G., De, M., Kim, C. K., & Rotello, V. M. (2008). Gold nanoparticles in delivery applications. Advanced Drug Delivery Reviews, 60(11), 1307–1315.PubMedGoogle Scholar
  58. 58.
    Lipka, J., et al. (2010). Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection. Biomaterials, 31(25), 6574–6581.PubMedGoogle Scholar
  59. 59.
    Truong, N. P., Whittaker, M. R., Mak, C. W., & Davis, T. P. (2015). The importance of nanoparticle shape in cancer drug delivery. Expert Opinion on Drug delivery, 12(1), 129–142.PubMedGoogle Scholar
  60. 60.
    Kel, A. E., et al. (2016). Multi-omics “upstream analysis” of regulatory genomic regions helps identifying targets against methotrexate resistance of colon cancer. EuPA Open Proteomics, 13, 1–13.PubMedPubMedCentralGoogle Scholar
  61. 61.
    Rizk, N., Christoforou, N., & Lee, S. (2016). Optimization of anti-cancer drugs and a targeting molecule on multifunctional gold nanoparticles. Nanotechnology, 27(18), 185704.PubMedGoogle Scholar
  62. 62.
    Heo, D. N., et al. (2012). Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy. Biomaterials, 33(3), 856–866.PubMedGoogle Scholar
  63. 63.
    Lin, W., et al. (2017). pH-responsive unimolecular micelle-gold nanoparticles-drug nanohybrid system for cancer theranostics. Acta Biomaterialia, 58, 455–465. 2017/08/01/.PubMedGoogle Scholar
  64. 64.
    Zou, L., et al. (2016). Current approaches of photothermal therapy in treating cancer metastasis with nanotherapeutics. Theranostics, 6(6), 762.PubMedPubMedCentralGoogle Scholar
  65. 65.
    Li, J.-L., & Gu, M. (2010). Gold-nanoparticle-enhanced cancer photothermal therapy. IEEE Journal of Selected Topics in Quantum Electronics, 1(4), 989–996.Google Scholar
  66. 66.
    Abadeer, N. S., & Murphy, C. J. (2016). Recent progress in cancer thermal therapy using gold nanoparticles. The Journal of Physical Chemistry C, 120(9), 4691–4716.Google Scholar
  67. 67.
    Cheng, X., Sun, R., Yin, L., Chai, Z., Shi, H., & Gao, M. (2017). Light-triggered assembly of gold nanoparticles for photothermal therapy and photoacoustic imaging of tumors in vivo. Advanced Materials, 29(6), 1604894.Google Scholar
  68. 68.
    Hwang, S., Nam, J., Jung, S., Song, J., Doh, H., & Kim, S. (2014). Gold nanoparticle-mediated photothermal therapy: current status and future perspective. Nanomedicine, 9(13), 2003–2022.PubMedGoogle Scholar
  69. 69.
    Yu, M., Guo, F., Wang, J., Tan, F., & Li, N. (2015). Photosensitizer-loaded pH-responsive hollow gold nanospheres for single light-induced photothermal/photodynamic therapy. ACS Applied Materials & Interfaces, 7(32), 17592–17597.Google Scholar
  70. 70.
    Ling-Yu, B., et al. (2015). Multifunctional magnetic-hollow gold nanospheres for bimodal cancer cell imaging and photothermal therapy. Nanotechnology, 26(31), 315701.Google Scholar
  71. 71.
    Haume, K., et al. (2016). Gold nanoparticles for cancer radiotherapy: a review. Cancer Nanotechnology, 7(1), 8.PubMedPubMedCentralGoogle Scholar
  72. 72.
    Cooper, D. R., Bekah, D., & Nadeau, J. L., "Gold nanoparticles and their alternatives for radiation therapy enhancement," (in English), Frontiers in Chemistry, Review vol. 2, no. 86, 2014-October-14 2014.Google Scholar
  73. 73.
    Her, S., Jaffray, D. A., & Allen, C. (2015). Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements. Advanced Drug Delivery Reviews, 109, 84–101.PubMedGoogle Scholar
  74. 74.
    Dou, Y., et al. (2016). Size-tuning ionization to optimize gold nanoparticles for simultaneous enhanced CT imaging and radiotherapy. Acs Nano, 10(2), 2536–2548.PubMedGoogle Scholar
  75. 75.
    Guo, M., Sun, Y., & Zhang, X.-D. (2017). Enhanced radiation therapy of gold nanoparticles in liver cancer. Applied Sciences, 7(3), 232.Google Scholar
  76. 76.
    Ma, N., et al. (2017). Shape-dependent radiosensitization effect of gold nanostructures in cancer radiotherapy: comparison of gold nanoparticles, nanospikes, and nanorods. ACS Applied Materials & interfaces, 9(15), 13037–13048.Google Scholar
  77. 77.
    Hainfeld, J. F., & Smilowitz, H. M. (2015). Abstract 1807: Nuclear targeted gold nanoparticles for radiation enhancement. Cancer Research, 75(15 Supplement), 1807–1807.Google Scholar
  78. 78.
    Popovtzer, A., et al. (2016). Actively targeted gold nanoparticles as novel radiosensitizer agents: an in vivo head and neck cancer model. Nanoscale, 8(5), 2678–2685.PubMedGoogle Scholar
  79. 79.
    Liang, G., Jin, X., Zhang, S., & Xing, D. (2017). RGD peptide-modified fluorescent gold nanoclusters as highly efficient tumor-targeted radiotherapy sensitizers. Biomaterials, 144, 95–104.PubMedGoogle Scholar

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Authors and Affiliations

  • Negar Sedghi Aminabad
    • 1
  • Masoud Farshbaf
    • 1
  • Abolfazl Akbarzadeh
    • 2
    • 3
    Email author
  1. 1.Department of Medical Nanotechnology, Faculty of Advanced Medical ScienceTabriz University of Medical ScienceTabrizIran
  2. 2.Biotechnology Research CenterTabriz University of Medical SciencesTabrizIran
  3. 3.Department of Chemical Engineering, College of EngineeringNortheastern UniversityBostonUSA

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