Recent Advances of Gold Nanoparticles in Biomedical Applications: State of the Art

  • Negar Sedghi Aminabad
  • Masoud Farshbaf
  • Abolfazl AkbarzadehEmail author
Review Paper


Nanomedicine is one of the growing fields that presents new techniques for cancer diagnosis and treatment. Gold nanoparticles (GNPs) are considered as an important class of nanomaterials that possess superior physicochemical properties that make them valuable in medical applications. Unique optical properties of GNPs and their utility in photothermal and radiotherapy have extended a new platform for early detection and treatment of cancer, lately. Nanostructures based on GNPs are nontoxic and biocompatible with a large surface area that makes it possible to modify their surface with different chemicals including different polymers, antibodies, and even drug molecules. Therefore, they are utilized for targeted drug delivery in order to carry drugs and selectively release them in desired tissues which reduces destructive effects on healthy cells while it elevates the drug dose in cancerous ones. This review mainly covers the basic properties of GNPs, their synthesis methods, and focuses on surface modification of these nanoparticles and their diagnosis and therapeutic applications in cancer.


Gold nanoparticles Cancer therapy Surface plasmon resonance Imaging Photothermal therapy 



This work is funded by the 2017 Biotechnology Research Center, Tabriz University of Medical Sciences Grant. The authors would like to express their appreciation to Soodabeh Davaran and Ebrahim Mostafavi for their kind support and assistance with this review.

Author contributions

A.A. and M.F. conceived the study and participated in its design and coordination. N.S.A. participated in the sequence alignment and drafted the manuscript. S.D. and E.M. revised the manuscript. All authors read and approved the final manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

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Authors and Affiliations

  • Negar Sedghi Aminabad
    • 1
  • Masoud Farshbaf
    • 1
  • Abolfazl Akbarzadeh
    • 2
    • 3
    Email author
  1. 1.Department of Medical Nanotechnology, Faculty of Advanced Medical ScienceTabriz University of Medical ScienceTabrizIran
  2. 2.Biotechnology Research CenterTabriz University of Medical SciencesTabrizIran
  3. 3.Department of Chemical Engineering, College of EngineeringNortheastern UniversityBostonUSA

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