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Cell Biochemistry and Biophysics

, Volume 73, Issue 2, pp 349–355 | Cite as

Exacerbation of Chronic Obstructive Pulmonary Disease

  • Xianghui Zhou
  • Qingling LiEmail author
  • Xincan Zhou
Original Paper

Abstract

Chronic obstructive pulmonary disease (COPD) is a disease with high prevalence and substantial associated economical burden. A significant determinant of quality of life, long-term survival, and health care costs is an acute exacerbation of COPD. Acute exacerbations are provoked by respiratory viruses, altered airway microbiome, and environmental factors. The current treatment options are limited. In order to develop specific therapeutic measures, it is important to understand how acute exacerbations evolve. This review focuses on pathophysiology of stable and exacerbated COPD.

Keywords

COPD Exacerbation Virus Bacteria Innate immunity Inflammation Review 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Respiratory MedicineThe First Xuzhou People’s HospitalXuzhouChina

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