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Cell Biochemistry and Biophysics

, Volume 70, Issue 2, pp 845–855 | Cite as

Biochemical Modifications and Neuronal Damage in Brain of Young and Adult Rats After Long-Term Exposure to Mobile Phone Radiations

  • Tarek K. Motawi
  • Hebatallah A. DarwishEmail author
  • Yasser M. Moustafa
  • Mohammed M. Labib
Original Paper

Abstract

This study investigated the effect of exposure to mobile phone radiations on oxidative stress and apoptosis in brain of rats. Rats were allocated into six groups (three young and three adult). Groups 1 and 4 were not subjected to the radiation source and served as control groups. In groups 2 and 5, the mobile phones were only connected to the global system for mobile communication, while in groups 3 and 6, the option of calling was in use. Microwaves were generated by a mobile test phone (SAR = 1.13 W/kg) during 60 days (2 h/day). Significant increments in conjugated dienes, protein carbonyls, total oxidant status, and oxidative stress index along with a significant reduction of total antioxidant capacity levels were evident after exposure. Bax/Bcl-2 ratio, caspase-3 activity, and tumor necrosis factor-alpha level were enhanced, whereas no DNA fragmentation was detected. The relative brain weight of young rats was greatly affected, and histopathological examination reinforced the neuronal damage. The study highlights the detrimental effects of mobile phone radiations on brain during young and adult ages. The interaction of these radiations with brain is via dissipating its antioxidant status and/or triggering apoptotic cell death.

Keywords

Mobile phone Brain Oxidative stress Apoptosis Neuronal damage Rats 

Abbreviations

Bax

Bcl-2-associated X protein

BBB

Blood brain barrier

Bcl- 2

Beta cell lymphoma-2

EMF

Electromagnetic field

EMR

Electromagnetic radiation

FRs

Free radicals

GSM

Global system for mobile communication

MWs

Microwaves

OSI

Oxidative stress index

Pr Co

Protein carbonyls

ROS

Reactive oxygen species

SAR

Specific absorption rate

TAC

Total antioxidant capacity

TNF-α

Tumor necrosis factor-alpha

TOS

Total oxidant status

Notes

Acknowledgments

The authors gratefully acknowledge the financial assistance provided by the Faculty of Pharmacy, Cairo University, Egypt. The authors are also thankful to Dr Adel Bakeer, Histology Department, Faculty of Veterinary Medicine, Cairo University, for performing the histopathological examination in this study.

Conflict of interest

The authors declare that there are no conflicts of interest.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Tarek K. Motawi
    • 1
  • Hebatallah A. Darwish
    • 1
    Email author
  • Yasser M. Moustafa
    • 2
  • Mohammed M. Labib
    • 1
  1. 1.Department of Biochemistry, Faculty of PharmacyCairo UniversityCairoEgypt
  2. 2.Department of Pharmacology and Toxicology, Faculty of PharmacySuez Canal UniversityIsmailiaEgypt

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