Cell Biochemistry and Biophysics

, Volume 70, Issue 1, pp 499–504

Ultrasound-Microbubble Transplantation of Bone Marrow Stromal Cells Improves Neurological Function after Forebrain Ischemia in Adult Mice

  • Zili Gong
  • Hong Ran
  • Shengzheng Wu
  • Jie Zhu
  • Jian Zheng
Original Paper


In this study, bone marrow stromal cells (MSCs) were transplanted into the brain of adult rats after forebrain ischemia induced by 4VO. SD rats (n = 60) were randomly divided into three groups: (I) rats (n = 20) were subjected to 4VO and transplanted with MSCs into the ischemic region using ultrasound-microbubble method, (2) rats (n = 20) were subjected to 4VO and transplanted with MSCs into the ischemic region (n = 20), and (3) 4VO alone (n = 20). Rats were sacrificed 28 days after treatment. Neurological functions of rats were evaluated by Morris Water Maze. The current findings suggest that the ultrasound microbubble transplanted MSCs survived in the ischemic brain and significantly improved functional recovery of adult rats compared to regular transplantation.


Bone marrow stromal cells Ultrasound microbubble Forebrain ischemia 


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Zili Gong
    • 1
  • Hong Ran
    • 1
  • Shengzheng Wu
    • 2
  • Jie Zhu
    • 3
  • Jian Zheng
    • 1
  1. 1.Department of Neurology, Xinqiao HospitalThird Military Medical UniversityChongqingChina
  2. 2.Department of Ultrasound, Xinqiao HospitalThird Military Medical UniversityChongqiChina
  3. 3.Department of Neurology, Daping HospitalThird Military Medical UniversityChongqiChina

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