Cell Biochemistry and Biophysics

, Volume 69, Issue 3, pp 405–409

Side Effects of Long-Acting Local Anaesthetics in Patients with Preexisting Cardiovascular Condition

Review Paper

DOI: 10.1007/s12013-014-9851-5

Cite this article as:
Zhang, X., Zhang, L. & Zhang, Y. Cell Biochem Biophys (2014) 69: 405. doi:10.1007/s12013-014-9851-5


The oral surgical anaesthesia is field in which usually long-acting local anaesthetics are being used. Some of the currently used acting local anaesthetics as Levobupivacaine or Ropivacaine have reduced cardiac toxicity. The aim of this review is to provide an overview of acting mechanisms when anaesthetic agents are applied in oral surgery and the effect that they may have in patients with chronic concurrent cardiac conditions. There are notable linking the property of the local anaesthetics lipid solubility and the potency of local anaesthetic-induced vasoconstriction which can additionally compromise cardiac function in patients with previously impaired cardiac function.


Levobupivacaine Local anaesthetics Cardiovascular condition Postoperative analgesia 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of AnesthesiologyFirst Hospital of Jilin UniversityChangchunChina
  2. 2.The Reproductive Medical CentreFirst Hospital of Jilin UniversityChangchunChina
  3. 3.Department of NeurosurgeryFirst Hospital of Jilin UniversityChangchunChina

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