Revealing the Strong Functional Association of adipor2 and cdh13 with adipoq: A Gene Network Study
In the present study, we have analyzed functional gene interactions of adiponectin gene (adipoq). The key role of adipoq is in regulating energy homeostasis and it functions as a novel signaling molecule for adipose tissue. Modules of highly inter-connected genes in disease-specific adipoq network are derived by integrating gene function and protein interaction data. Among twenty genes in adipoq web, adipoq is effectively conjoined with two genes: Adiponectin receptor 2 (adipor2) and cadherin 13 (cdh13). The functional analysis is done via ontological briefing and candidate disease identification. We observed that the highly efficient-interlinked genes connected with adipoq are adipor2 and cdh13. Interestingly, the ontological aspect of adipor2 and cdh13 in the adipoq network reveal the fact that adipoq and adipor2 are involved mostly in glucose and lipid metabolic processes. The gene cdh13 indulge in cell adhesion process with adipoq and adipor2. Our computational gene web analysis also predicts potential candidate disease recognition, thus indicating the involvement of adipoq, adipor2, and cdh13 with not only with obesity but also with breast cancer, leukemia, renal cancer, lung cancer, and cervical cancer. The current study provides researchers a comprehensible layout of adipoq network, its functional strategies and candidate disease approach associated with adipoq network.
KeywordsGene networks Adipoq Adipor2 Cdh13 Obesity
Adiponectin receptor 2
Search tool for retrieval of interacting genes/protein
Protein interaction network analysis
Database of interacting proteins
Biomolecular interaction network database
Human protein reference database
A.A. gratefully acknowledges the Indian council of Medical Research (ICMR), Government of India Agency for the research Grant [IRIS ID: 2014-0099]. S.B. thanks ICMR for the Senior Research Fellowship. The authors would also like to thank the management of VIT University for providing the necessary facilities to carry out this research project.
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