Cell Biochemistry and Biophysics

, Volume 70, Issue 3, pp 1617–1623 | Cite as

Evaluation of the Association Between CD143 Gene Polymorphism and Psoriasis

Original Paper

Abstract

Increased CD143 activity has been detected in various skin tissues, and this increase is partially caused by the intronic ID polymorphism. The genetic contribution of CD143 ID polymorphism to the progression of psoriasis, the commonest skin disease, has been extensively investigated, but reported with inconsistent results. The aim of this work was to gain new insights to shed light on the association between CD143 ID polymorphism and psoriasis risk. We systematically identified the studies examining the association of CD143 ID polymorphism with psoriasis risk. A meta-analysis combining data from all eligible studies was carried out. To evaluate the genetic association, we calculated odds ratio (OR) and its 95 % confidence intervals (CIs) for both genotypic models and allelic model. The final pooling dataset comprised ten studies. Meta-analysis of total samples did not suggest a notable association with psoriasis risk. However, subgroup analysis by ethnicity revealed a statistically significant association in East Asian samples (DD + ID vs. II: OR 0.86, 95 % CI 0.75–0.99, Pheterogeneity = 0.970; DD vs. ID: OR 0.85, 95 % CI 0.73–0.99, Pheterogeneity = 0.868; D vs. I: OR 0.86, 95 % CI 0.76–0.97, Pheterogeneity = 0.994). This meta-analysis demonstrated that the presence of CD143 ID polymorphism may modify the risk of psoriasis in individuals with East Asian ancestry.

Keywords

CD143 Insertion/deletion polymorphism Psoriasis risk 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Chinese PLA General HospitalBeijingChina
  2. 2.Department of Dermatology306 Hospital of PLABeijingChina
  3. 3.Department of Neuro-Oncology SurgeryThe General Hospital of Chinese People’s Armed Police ForcesBeijingChina
  4. 4.Department of Intensive Care MedicineJinan Military General HospitalJinanChina
  5. 5.Department of HealthManagement Security Department of General Staff, PLABeijingChina
  6. 6.Department of Stomatology306 Hospital of PLABeijingChina
  7. 7.Department of DermatologyChinese PLA General HospitalBeijingChina

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