Cell Biochemistry and Biophysics

, Volume 70, Issue 2, pp 1479–1488 | Cite as

Polar Characterization of Antifungal Peptides from APD2 Database

  • Carlos Polanco
  • José Lino Samaniego-Mendoza
  • Thomas Buhse
  • Jorge Alberto Castañón-González
  • Marili Leopold-Sordo
Original Paper


The increase in the number of pathogens due to fungi that are tolerant to therapies does not grow at the same speed than the advance on new antifungal drugs. In this sense, it is imperative to find anti-fungi peptides that are not detrimental to mammalian cells and have an effective toxicity to fungi. In this work, we use a method called polarity index, to identify anti-fungi peptides with an efficiency of 70 %. This method already published, initially identified selective antibacterial peptides from APD2 Database, and was characterized by developing a comprehensive analysis of the polar dynamics of a peptide from its linear sequence. Discriminating tests showed that in addition to being efficient in this identification, it was also good at rejecting other classifications of peptides found in that same database.


Polarity index method Selective antibacterial peptides Anti-fungi peptides 



Selective cationic amphipathic antibacterial peptides


Antimicrobial peptide database


Quantitative structure activity relationships



The authors acknowledge the Departamento de Cómputo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán for support, and the proof-reading of this manuscript by Concepción Celis Juárez.

Conflict of interest

We declare that we do not have any financial and personal interest with other people or organizations that could inappropriately influence (bias) our work.

Supplementary material

12013_2014_85_MOESM1_ESM.gif (1 kb)
Supplementary material 1 (GIF 1 kb)


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Carlos Polanco
    • 1
    • 2
  • José Lino Samaniego-Mendoza
    • 1
    • 2
  • Thomas Buhse
    • 3
  • Jorge Alberto Castañón-González
    • 1
  • Marili Leopold-Sordo
    • 1
  1. 1.Facultad de Ciencias de la SaludUniversidad AnáhuacHuixquilucanMexico
  2. 2.Departamento de Matemáticas, Facultad de CienciasUniversidad Nacional Autónoma de MéxicoD.FMexico
  3. 3.Centro de Investigaciones QuímicasUniversidad Autónoma del Estado de MorelosCuernavacaMexico

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