Cell Biochemistry and Biophysics

, Volume 68, Issue 3, pp 475–478 | Cite as

Citric Acid Cycle and Role of its Intermediates in Metabolism

  • Muhammad Akram
Review Paper


The citric acid cycle is the final common oxidative pathway for carbohydrates, fats and amino acids. It is the most important metabolic pathway for the energy supply to the body. TCA is the most important central pathway connecting almost all the individual metabolic pathways. In this review article, introduction, regulation and energetics of TCA cycle have been discussed. The present study was carried out to review literature on TCA cycle.


TCA cycle Energetics of TCA cycle Regulation of TCA cycle Amphibolic role of TCA cycle 


  1. 1.
    Abdel-aleem, S., Nada, M. A., Sayed-Ahmed, M., Hendrickson, S. C., St Louis, J., Walthall, H. P., et al. (1996). Regulation of fatty acid oxidation by acetyl-CoA generated from glucose utilization in isolated myocytes. Journal of Molecular and Cellular Cardiology, 28(5), 825–833.PubMedCrossRefGoogle Scholar
  2. 2.
    Akiba, T., Hiraga, K., & Tuboi, S. (1984). Intracellular distribution of fumarase in various animals. Journal of Biochemistry (Tokyo), 96, 189–195.Google Scholar
  3. 3.
    Baldwin, J. E., & Krebs, H. (1981). The evaluation of metabolic cycle. Nature, 292, 291–381.CrossRefGoogle Scholar
  4. 4.
    Bowtell, J. L., Marwood, S., Bruce, M., Constantin-Teodosiu, D., & Greenhaff, P. L. (2007). Tricarboxylic acid cycle intermediate pool size: Functional importance for oxidative metabolism in exercising human skeletal muscle. Sports Medicine (Auckland, N. Z.), 37(12), 1071–1088.CrossRefGoogle Scholar
  5. 5.
    Briere, J. J., Favier, J., El Ghouzzi, V., Djouadi, F., Benit, P., Gimenez, A. P., et al. (2005). Succinate dehydrogenase deficiency in human. Cellular and Molecular Life Sciences, 62, 2317–2324.PubMedCrossRefGoogle Scholar
  6. 6.
    Costello, L. C., & Franklin, R. B. (1981). Aconitase activity, citrate oxidation, and zinc inhibition in rat ventral prostate. Enzyme, 26, 281–287.PubMedGoogle Scholar
  7. 7.
    Fonnum, F., Johnsen, A., & Hassel, B. (1997). Use of fluorocitrate and fluoroacetate in the study of brain metabolism. Glia, 21(1), 106–113.PubMedCrossRefGoogle Scholar
  8. 8.
    Hellemond, J. J., Opperdoes, F. R., & Tielens, A. G. (2005). The extraordinary mitochondrion and unusual citric acid cycle in Trypanosoma brucei van. Biochemical Society Transactions, 33(5), 967–971.PubMedCrossRefGoogle Scholar
  9. 9.
    Jones, J. G., Sherry, A. D., Jeffrey, F. M., Storey, C. J., & Malloy, C. R. (1993). Sources of acetyl-CoA entering the tricarboxylic acid cycle as determined by analysis of succinate 13C isotopomers. Biochemistry, 32(45), 12240–12244.PubMedCrossRefGoogle Scholar
  10. 10.
    Kamzolova, S. V., Shishkanova, N. V., Morgunov, I. G., & Finogenova, T. V. (2003). Oxygen requirements for growth and citric acid production of Yarrowia lipolytica. FEMS Yeast Research, 3(2), 217–222.PubMedCrossRefGoogle Scholar
  11. 11.
    Krebs, H. A. (1970). The history of the tricarboxylic acid cycle. Perspectives in Biology and Medicine, 14(1), 154–170.PubMedGoogle Scholar
  12. 12.
    Melendez, E., Waddell, T., & Cascante, M. (1996). The puzzle of the citric acid cycle. Journal of Molecular Evolution, 43, 293–303.CrossRefGoogle Scholar
  13. 13.
    Nazaret, C., Heiske, M., Thurley, K., & Mazat, J. P. (2009). Mitochondrial energetic metabolism: A simplified model of TCA cycle with ATP production. Journal of Theoretical Biology, 258(3), 455–464.PubMedCrossRefGoogle Scholar
  14. 14.
    Reeds, P. J., Berthold, H. K., Boza, J. J., Burrin, D. G., Jahoor, F., Jaksic, T., et al. (1997). Integration of amino acid and carbon intermediary metabolism: Studies with uniformly labeled tracers and mass isotopomer analysis. European Journal of Pediatrics, 156(1), 50–58.CrossRefGoogle Scholar
  15. 15.
    Srere, P. A. (1975). The enzymology of the formation and breakdown of citrate. Advanced Enzymology, 43, 57.Google Scholar
  16. 16.
    Wan, B., LaNoue, K. F., Cheung, J. Y., & Scaduto, R. C, Jr. (1989). Regulation of citric acid cycle by calcium. Journal of Biological Chemistry, 264(23), 13430–13439.PubMedGoogle Scholar
  17. 17.
    Zatta, P., Lain, E., & Cagnolini, C. (2000). Effects of aluminum on activity of Krebs cycle enzymes and glutamate dehydrogenase in rat brain homogenate. European Journal of Biochemistry, 267(10), 3049–3055.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Eastern Medicine and Surgery, Faculty of Medical and Health SciencesThe University of PoonchAzad Jammu and KashmirPakistan

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