Cell Biochemistry and Biophysics

, Volume 68, Issue 3, pp 555–559 | Cite as

Complete Radiofrequency Ablation of Hepatolithiasis-Associated Cholangiocarcinoma and Successful Management of Post-ablation Bronchobiliary Fistula

  • Kai Jiang
  • Ming Su
  • Wenzhi Zhang
  • Xiangqian Zhao
  • Jing Wang
  • Jiahong Dong
  • Zhiqiang Huang
Original Paper


This report documented the use of radiofrequency ablation (RFA) in the treatment of hepatolithiasis-associated cholangiocarcinoma and cyanoacrylate glue in the management of post-ablation bronchobiliary fistula. A 47-year-old Chinese woman with 20 years history of extrahepatic and intrahepatic cholangiolithiasis and multiple hepatic segmentectomy, developed hepatolithiasis-associated cholangiocarcinoma. The tumor was successfully treated with RFA but patient developed bronchobiliary fistula. Cyanoacrylate glue was used for occluding the bronchobiliary fistula. CT scan at 3 months showed complete restoration of physiological separation between the biliary and bronchial system. Repeat CT scan showed complete tumor ablation with no signs of tumor recurrence 10 months after RFA. In conclusion, RFA may be a safe and effective treatment option for patients with hepatolithiasis-associated cholangiocarcinoma who are poor candidates for surgical resection. Protection of the integrity of the bile duct and diaphragm during RFA can minimize postoperative complications. In case of development of post-ablation bronchobiliary fistula, cyanoacrylate glue can be used to occlude the fistula, before surgical resection is considered.


Cholangiocarcinoma Hepatolithiasis Radiofrequency ablation Bronchobiliary fistula Treatment Integrity 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Kai Jiang
    • 1
  • Ming Su
    • 1
  • Wenzhi Zhang
    • 1
  • Xiangqian Zhao
    • 1
  • Jing Wang
    • 1
  • Jiahong Dong
    • 1
  • Zhiqiang Huang
    • 1
  1. 1.Institute & Hospital of Hepatobiliary Surgery, Key Laboratory of Digital Hepatobiliary Surgery of Chinese PLAChinese PLA Medical School, Chinese PLA General HospitalBeijingChina

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