Cell Biochemistry and Biophysics

, Volume 68, Issue 2, pp 379–385

Oxidized Low-Density Lipoprotein and C-Reactive Protein Have Combined Utility for Better Predicting Prognosis After Acute Coronary Syndrome

  • Ya-chen Zhang
  • Yong Tang
  • Yu Chen
  • Xiao-hong Huang
  • Min Zhang
  • Jian Chen
  • Ying-gang Sun
  • Yi-gang Li
Original Paper

Abstract

It has been shown that the elevated concentrations of oxidized low-density lipoprotein (Ox-LDL) or high-sensitivity C-reactive protein (hs-CRP) are predictive of future cardiovascular events for acute coronary syndrome (ACS) patients. But, the combined value of Ox-LDL and hs-CRP for predicting cardiovascular events is still unknown. Serum concentrations of Ox-LDL, hs-CRP, and cTnT were measured in a prospective cohort of 425 selective ACS patients followed 3–5 years for the occurrence of acute myocardial infarction (AMI) or death (AMI/death). Among 425 enrolled patients, 124 patients demonstrated AMI/death. Baseline levels of Ox-LDL, hs-CRP, and cTnT were significantly higher in AMI/death group than the event-free survival group. Kaplan–Meier survival analyses supported that elevations in Ox-LDL or hs-CRP predicted increased cardiovascular events risks. However, the strongest risk prediction was achieved by assessing Ox-LDL and hs-CRP together. Patients with high levels of Ox-LDL and hs-CRP were more likely to experience AMI or death than those with either Ox-LDL or hs-CRP elevated. Receiver-operating characteristic curves showed that Ox-LDL and hs-CRP have higher sensitivity and specificity than those of cTnT for predicting AMI or death. This was reflected by the AUC values for Ox-LDL, hs-CRP, and cTnT, which were 0.891, 0.834, and 0.626, respectively. The combined use of Ox-LDL and hs-CRP may improve prognosis after ACS with high-sensitivity and specificity.

Keywords

Acute coronary syndrome Prognosis Oxidized LDL C-reactive protein Myocardial infarction 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Ya-chen Zhang
    • 1
  • Yong Tang
    • 1
  • Yu Chen
    • 1
  • Xiao-hong Huang
    • 1
  • Min Zhang
    • 1
  • Jian Chen
    • 1
  • Ying-gang Sun
    • 1
  • Yi-gang Li
    • 1
  1. 1.Division of Cardiology, Xinhua Hospital School of MedicineShanghai Jiaotong UniversityShanghaiChina

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